Uesaka S, Nakayama Y, Shirai Y, Yoshihara K
Department of Orthopaedic Surgery, Nippon Medical School, Kawasaki, Kanagawa, Japan.
J Nippon Med Sch. 2001 Apr;68(2):165-70. doi: 10.1272/jnms.68.165.
We measured serum and synovial fluid levels of chondroitin sulfate (CS) in patients with osteoarthritis (OA) of the knee joint to clarify whether CS levels differ in various stages of OA, and whether measurement of CS levels is useful in evaluating the pathology of OA. The study population was 117 OA patients and 23 healthy young volunteers. Synovial fluid was obtained from 69 of 117 OA patients. The mean serum level of C4S in all of the OA patients was significantly higher than that in the controls (p< 0.05). However, there was little difference between respective OA stages. A small amount of serum C6S (0.2 to 0.6 nmol/ml) was detected in 31.6% of the OA patients and in 26.1%of the control subjects. The mean serum C0S level in all OA patients was significantly higher than that in the controls (p< 0.01). However no significant difference was found between respective OA stages. As for synovial fluid CS, the C4S level in the early stage of OA tended to be higher than that in the advanced stage. C6S levels showed a markedly decreasing trend with advancing OA stage. C0S was not detected in synovial fluid. The present study demonstrated that serum levels of C4S and C0S in OA patients are elevated compared with normal subjects, and that synovial fluid levels of C4S and C6S may provide useful in assessing the pathology of OA.
我们测量了膝关节骨关节炎（OA）患者血清和滑液中硫酸软骨素（CS）的水平，以明确CS水平在OA各阶段是否存在差异，以及CS水平测量在评估OA病理方面是否有用。研究对象为117例OA患者和23名健康年轻志愿者。117例OA患者中的69例获取了滑液。所有OA患者血清中C4S的平均水平显著高于对照组（p<0.05）。然而，各OA阶段之间差异不大。31.6%的OA患者和26.1%的对照者检测到少量血清C6S（0.2至0.6 nmol/ml）。所有OA患者血清C0S的平均水平显著高于对照组（p<0.01）。然而，各OA阶段之间未发现显著差异。至于滑液CS，OA早期的C4S水平往往高于晚期。随着OA阶段的进展，C6S水平呈明显下降趋势。滑液中未检测到C0S。本研究表明，与正常受试者相比，OA患者血清中C4S和C0S水平升高，且滑液中C4S和C6S水平可能有助于评估OA的病理情况。
