Marsella R, Nicklin C F
Blanche Saunders Dermatology Laboratory, Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, PO Box 100126, Gainesville, FL 32610-0126, USA.
Vet Dermatol. 2001 Feb;12(1):3-12. doi: 10.1046/j.1365-3164.2001.00203.x.
Pathogenesis of canine atopy has not been completely elucidated. In humans, sulphido-leukotrienes (s-LT) play a role in atopy, and increased production of s-LT occurs in the skin and peripheral leukocytes after allergen challenge. The study population included 16 clinically normal and 13 atopic dogs. All atopic dogs had in common a positive reaction (4+) to the intradermal injection of house dust mite (allergen of reference). Blood samples and skin biopsies were collected. Sulphido-LT synthesis by peripheral leukocytes after stimulation was measured, and no statistically significant difference was found between clinically normal and atopic dogs. Sulphido-LT concentrations in skin samples from stimulated and unstimulated sites were measured, and no statistically significant difference was detected between clinically normal and atopic dogs or between lesional and nonlesional skin within the atopic group. Clinical signs of atopic dogs were graded by owners and no correlation was found between their severity and cutaneous concentrations of s-LT. In this study there was no increase in s-LT synthesis in atopic dogs.
犬特应性皮炎的发病机制尚未完全阐明。在人类中，硫代白三烯（s-LT）在特应性皮炎中起作用，过敏原激发后皮肤和外周白细胞中s-LT的产生会增加。研究对象包括16只临床正常的犬和13只患特应性皮炎的犬。所有患特应性皮炎的犬对皮内注射屋尘螨（参考过敏原）均有阳性反应（4+）。采集了血样和皮肤活检样本。测定了刺激后外周白细胞中硫代白三烯的合成，结果发现临床正常犬和患特应性皮炎的犬之间无统计学显著差异。测量了刺激部位和未刺激部位皮肤样本中硫代白三烯的浓度，结果发现临床正常犬和患特应性皮炎的犬之间以及患特应性皮炎组的皮损皮肤和非皮损皮肤之间均未检测到统计学显著差异。患特应性皮炎的犬的临床症状由主人进行分级，结果发现其严重程度与皮肤中硫代白三烯的浓度之间无相关性。在本研究中，患特应性皮炎的犬的硫代白三烯合成未增加。
