维生素D对正常受试者及服用抗惊厥药的癫痫患者骨矿物质含量的影响：一项对照治疗试验。
Effect of vitamin D on bone mineral mass in normal subjects and in epileptic patients on anticonvulsants: a controlled therapeutic trial.
作者信息
Christiansen C, Rodbro P, Lund M
出版信息
Br Med J. 1973 Apr 28;2(5860):208-9. doi: 10.1136/bmj.2.5860.208.
Abstract
The bone mineral mass was estimated by photon absorptiometry in 23 epileptic patients on long-term treatment with phenytoin and in 20 normal subjects before and during treatment with vitamin D or placebo.Initially, subnormal values of bone mineral mass were found in the epileptic patients. The group of epileptic patients treated with vitamin D showed a significant increase in bone mineral mass. The group of epileptic patients treated with placebo and the normal subjects treated with vitamin D or placebo showed no change in bone mineral mass.
摘要
通过光子吸收法对23名长期接受苯妥英治疗的癫痫患者以及20名正常受试者在服用维生素D或安慰剂治疗前和治疗期间的骨矿物质含量进行了评估。最初，癫痫患者的骨矿物质含量值低于正常水平。接受维生素D治疗的癫痫患者组骨矿物质含量显著增加。接受安慰剂治疗的癫痫患者组以及接受维生素D或安慰剂治疗的正常受试者组骨矿物质含量没有变化。
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