嗜麦芽窄食单胞菌独特临床菌株的抗菌药敏性
Antimicrobial susceptibilities of unique Stenotrophomonas maltophilia clinical strains.
作者信息
Valdezate S, Vindel A, Loza E, Baquero F, Cantón R
机构信息
Servicio de Microbiología, Hospital Ramón y Cajal, Madrid-28034, Spain.
出版信息
Antimicrob Agents Chemother. 2001 May;45(5):1581-4. doi: 10.1128/AAC.45.5.1581-1584.2001.
Abstract
Susceptibility to 41 antimicrobials was studied with 99 Stenotrophomonas maltophilia strains, and different pulsed-field gel electrophoresis profiles were identified among 130 prospectively collected isolates. Moxalactam, doxycycline, minocycline, and clinafloxacin displayed the highest activity (> or = 98% susceptibility). Ticarcillin resistance (75%) was reverted by clavulanate in 25% of strains. Trimethoprim-sulfamethoxazole resistance was 26.2% (> or = 4 [trimethoprim]/76 [sulfamethoxazole] microg/ml) and dropped to 11.1% when an 8/152-microg/ml breakpoint was applied based on its bimodal MIC distribution. Resistance was lower when unique strains were considered, because clonal organisms contribute to resistance.
摘要
对99株嗜麦芽窄食单胞菌菌株进行了对41种抗菌药物的敏感性研究，并在130株前瞻性收集的分离株中鉴定出不同的脉冲场凝胶电泳图谱。莫拉酰胺、多西环素、米诺环素和克林沙星显示出最高活性（敏感性≥98%）。25%的菌株中，克拉维酸盐可逆转替卡西林耐药性（75%）。甲氧苄啶-磺胺甲恶唑耐药率为26.2%（≥4[甲氧苄啶]/76[磺胺甲恶唑]微克/毫升），基于其双峰MIC分布，当应用8/152微克/毫升的断点时，耐药率降至11.1%。当考虑单一菌株时，耐药性较低，因为克隆生物体导致耐药。
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