Colbert L H, Hartman T J, Malila N, Limburg P J, Pietinen P, Virtamo J, Taylor P R, Albanes D
Division of Clinical Sciences, National Cancer Institute, NIH, Bethesda, Maryland 20892-7058, USA.
Cancer Epidemiol Biomarkers Prev. 2001 Mar;10(3):265-8.
We examined the association between occupational and leisure physical activity and colorectal cancer in a cohort of male smokers. Among the 29,133 men aged 50-69 years in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention study,152 colon and 104 rectal cancers were documented during up to 12 years of follow-up. For colon cancer, compared with sedentary workers, men in light occupational activity had a relative risk (RR) of 0.60 [95% confidence interval (CI), 0.34-1.04], whereas those in moderate/heavy activity had an RR of 0.45 (CI, 0.26-0.78; P for trend, 0.003). Subsite analysis revealed a significant association for moderate/heavy occupational activity in the distal colon (RR, 0.21; CI, 0.09-0.51) but not in the proximal colon (RR, 0.87; CI, 0.40-1.92). There was no significant association between leisure activity and colon cancer (active versus sedentary; RR, 0.82; CI, 0.59-1.13); however, the strongest inverse association was found among those most active in both work and leisure (RR, 0.33; CI, 0.16-0.71). For rectal cancer, there were risk reductions for those in light (RR, 0.71; CI, 0.36-1.37) and moderate/heavy occupational activity (RR, 0.50; CI, 0.26-0.97; P for trend, 0.04), and no association for leisure activity. These data provide evidence for a protective role of physical activity in colon and rectal cancer.
我们在一组男性吸烟者中研究了职业和休闲体力活动与结直肠癌之间的关联。在α-生育酚、β-胡萝卜素癌症预防研究中，对29133名年龄在50至69岁的男性进行了研究，在长达12年的随访期间记录了152例结肠癌和104例直肠癌病例。对于结肠癌，与久坐不动的工人相比，从事轻度职业活动的男性相对风险（RR）为0.60[95%置信区间（CI），0.34 - 1.04]，而从事中度/重度活动的男性RR为0.45（CI，0.26 - 0.78；趋势P值，0.003）。亚部位分析显示，在远端结肠，中度/重度职业活动存在显著关联（RR，0.21；CI，0.09 - 0.51），而在近端结肠则无关联（RR，0.87；CI，0.40 - 1.92）。休闲活动与结肠癌之间无显著关联（活跃与久坐相比；RR，0.82；CI，0.59 - 1.13）；然而，在工作和休闲中都最活跃的人群中发现了最强的负相关（RR，0.33；CI，0.16 - 0.71）。对于直肠癌，从事轻度（RR，0.71；CI，0.36 - 1.37）和中度/重度职业活动的人群风险降低（RR，0.50；CI，0.26 - 0.97；趋势P值，0.04），休闲活动与之无关联。这些数据为体力活动在结肠癌和直肠癌中的保护作用提供了证据。
