Hartman T J, Tangrea J A, Pietinen P, Malila N, Virtanen M, Taylor P R, Albanes D
Divison of Clinical Science, National Cancer Institute, Bethesda, MD 20892, USA.
Nutr Cancer. 1998;31(1):41-8. doi: 10.1080/01635589809514676.
The association between coffee and black tea consumption and the subsequent risk of colon and rectal cancer was investigated within a Finnish clinical trial cohort. One hundred eleven cases of colon cancer and 83 cases of rectal cancer were diagnosed over a median of 9.0 years of follow-up. Proportional hazards regression models were used to derive adjusted relative risk (RR) and 95% confidence intervals (CI) for the association between coffee and tea consumption and cancer incidence. After controlling for confounders, coffee was not significantly associated with colon or rectal cancer. A positive association was seen for increased consumption of tea drinking and colon cancer. Compared with persons who did not drink tea, those who consumed <1 cup/day had an RR of 1.40 (95% CI = 0.84 - 2.33) and those who consumed > or = 1 cup/day had an RR of 2.09 (95% CI = 1.34-3.26, p for trend = 0.001). In contrast, tea consumption had little effect on rectal cancer incidence. This study does not support the hypothesis that coffee and tea protect against colorectal cancer risk. However, given the strength of the tea-colon cancer association and the significant gradient of risk we observed across level of intake, further epidemiologic research of this relationship in other populations seems warranted.
在芬兰一项临床试验队列中，研究了饮用咖啡和红茶与随后患结肠癌和直肠癌风险之间的关联。在中位随访9.0年期间，共诊断出111例结肠癌病例和83例直肠癌病例。采用比例风险回归模型来推导咖啡和茶饮用与癌症发病率之间关联的校正相对风险（RR）及95%置信区间（CI）。在控制混杂因素后，咖啡与结肠癌或直肠癌无显著关联。饮茶量增加与结肠癌呈正相关。与不饮茶者相比，每天饮用<1杯茶者的RR为1.40（95%CI=0.84-2.33），每天饮用≥1杯茶者的RR为2.09（95%CI=1.34-3.26，趋势p值=0.001）。相比之下，饮茶对直肠癌发病率影响较小。本研究不支持咖啡和茶可预防结直肠癌风险这一假设。然而，鉴于茶与结肠癌关联的强度以及我们观察到的摄入量水平与风险之间的显著梯度，在其他人群中对这种关系进行进一步的流行病学研究似乎是有必要的。
