Amirsasan Ramin, Akbarzadeh Maryam, Akbarzadeh Shabnam
Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Tabriz, Tabriz, Iran.
Department of Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran.
Cancer Cell Int. 2022 Aug 9;22(1):247. doi: 10.1186/s12935-022-02670-3.
Exercise and physical activity have been shown to be strongly associated with a decreased incidence rate of various chronic diseases especially numerous human malignancies. A huge number of clinical trials and meta-analysis have demonstrated that exercise is significantly effective in lowering the risk of colorectal cancer. In addition, it is suggested as an effective therapeutic modality against this cancer type. Therefore, in this review, we will review comprehensibly the effects of exercise in preventing, treating, and alleviating the adverse effects of conventional therapeutic options in colorectal cancer. Moreover, the possible mechanisms underlying the positive effects of exercise and physical activity in colorectal cancer, including regulation of inflammation, apoptosis, growth factor axis, immunity, epigenetic, etc. will be also discussed.
运动和体育活动已被证明与各种慢性疾病的发病率降低密切相关，尤其是众多人类恶性肿瘤。大量的临床试验和荟萃分析表明，运动在降低结直肠癌风险方面具有显著效果。此外，运动被认为是针对这种癌症类型的一种有效治疗方式。因此，在本综述中，我们将全面回顾运动在预防、治疗和减轻结直肠癌传统治疗方案不良反应方面的作用。此外，还将讨论运动和体育活动对结直肠癌产生积极影响的潜在机制，包括炎症调节、细胞凋亡、生长因子轴、免疫、表观遗传等方面。
