Villamil M F, Matloff J
Am J Physiol. 1975 Apr;228(4):1087-93. doi: 10.1152/ajplegacy.1975.228.4.1087.
Eight dogs were subjected to 80-90 percent coarctation of thoracic aorta, which produced a mean blood pressure gradient of 40 mmHg; six normal dogs were used as controls. Proximal aorta was compared with distal aorta, and carotid and femoral arteries removed after coarctation were compared against the contralateral vessels removed before coarctation. After 4 wk of coarctation, proximal aorta contained more total and intracellular Na (derived from 24Na fluxes and space measurements), more Mg, Cl, hydrolyzable SO4 equals to, and H2O than distal aorta. Hydrolyzable SO4 equals to was also higher in proximal than in distal noncoarcted aorta. Carotid arteries removed after coarctation had higher total and "noninulin" Na, higher Ca, and similar hydrolyzable SO4equals to and total hexosamine than the contralateral normal vessels. Aortic coarctation had no effect on ionic composition of femoral arteries. The data suggest that an increase in intravascular pressure has direct effects on vascular ionic composition. Although ionic changes may vary in different vessels, increased intracellular Na seems to be the most consistent finding.
八只狗接受了胸主动脉80% - 90%的缩窄，产生了平均40 mmHg的血压梯度；六只正常狗作为对照。将缩窄前的近端主动脉与远端主动脉进行比较，并将缩窄后切除的颈动脉和股动脉与缩窄前切除的对侧血管进行比较。缩窄4周后，近端主动脉比远端主动脉含有更多的总钠和细胞内钠（源自24钠通量和空间测量）、更多的镁、氯、可水解硫酸根离子和水。可水解硫酸根离子在近端未缩窄的主动脉中也比远端更高。缩窄后切除的颈动脉比另一侧正常血管含有更高的总钠和“非菊粉”钠、更高的钙，以及相似的可水解硫酸根离子和总己糖胺。主动脉缩窄对股动脉的离子组成没有影响。数据表明血管内压力升高对血管离子组成有直接影响。尽管不同血管中的离子变化可能不同，但细胞内钠增加似乎是最一致的发现。
