Pamnani M B, Overbeck H W
Circ Res. 1976 May;38(5):375-8. doi: 10.1161/01.res.38.5.375.
We examined the water, sodium, and potassium composition of the thoracic aorta, abdominal aorta (plus iliac arteries), and veins (vena cava and portal vein) from rats with aortic coarctation. The aortas of 10 rats (group A) were coarcted above the renal arteries to produce hypertension. Control groups consisted of 10 rats sham-coarcted above and 10 rats coarcted below the renal arteries. In group A rats heart weights and carotid artery pressures were elevated over controls (P less than 0.01), whereas there were no significant differences in femoral arterial pressures. In group A rats both the hypertensive thoracic aorta and the normotensive abdominal aorta contained about 20% more water per unit of wet weight, and about 35% and 60% more sodium and potassium, respectively, per unit of dry weight than did the corresponding portions of aorta from control rats (P less than 0.01). In group A rats water (P less than 0.01), sodium (P less than 0.02), and potassium (P less than 0.05) contents of veins also were increased. There were no significant correlations between level of carotid arterial pressure and magnitude of changes in arterial and venous composition, nor were there significant differences between the magnitude of changes in the normotensive and hypertensive portions of the aorta. These results indicate that in rats abnormalities in vascular wall salt and water content are not necessarily a direct effect of the elevated pressure in hypertension.
我们检测了主动脉缩窄大鼠的胸主动脉、腹主动脉（加髂动脉）以及静脉（腔静脉和门静脉）的水、钠和钾成分。将10只大鼠（A组）的主动脉在肾动脉上方缩窄以诱发高血压。对照组由10只在肾动脉上方进行假缩窄的大鼠和10只在肾动脉下方进行缩窄的大鼠组成。A组大鼠的心脏重量和颈动脉压力高于对照组（P<0.01），而股动脉压力无显著差异。与对照组大鼠主动脉的相应部分相比，A组大鼠的高血压胸主动脉和正常血压的腹主动脉每单位湿重的含水量均增加约20%，每单位干重的钠和钾含量分别增加约35%和60%（P<0.01）。A组大鼠静脉的水（P<0.01）、钠（P<0.02）和钾（P<0.05）含量也增加。颈动脉压力水平与动静脉成分变化幅度之间无显著相关性，主动脉正常血压部分和高血压部分的变化幅度之间也无显著差异。这些结果表明，在大鼠中，血管壁盐和水含量异常不一定是高血压中压力升高的直接影响。
