Berger Shelley L
The Wistar Institute, 3601 Spruce Street, Philadelphia, Pennsylvania 19104, USA.
Curr Opin Genet Dev. 2002 Apr;12(2):142-8. doi: 10.1016/s0959-437x(02)00279-4.
Covalent modifications of the amino termini of the core histones in nucleosomes have important roles in gene regulation. Research in the past two years reveals these modifications to consist of phosphorylation, methylation and ubiquitination, in addition to the better-characterized acetylation. This multiplicity of modifications, and their occurrence in patterns and dependent sequences, argues persuasively for the existence of a histone code.
核小体中核心组蛋白氨基末端的共价修饰在基因调控中发挥着重要作用。过去两年的研究表明，除了已被充分研究的乙酰化修饰外，这些修饰还包括磷酸化、甲基化和泛素化。修饰的多样性及其出现的模式和依赖序列，有力地证明了组蛋白密码的存在。
