Lew D, Rubey T, Krizan K, Keller J C
Dept. of Oral and Maxillofacial Surgery, The University of Iowa, USA.
Implant Dent. 2000;9(1):45-50. doi: 10.1097/00008505-200009010-00009.
Bioactive cements based on calcium phosphate chemistry have been developed to serve as bone substitute materials. One such commercial product, BoneSource, is a hydroxyapatite cement (HAC) used for small bone defects in the craniofacial complex. We have investigated the possibility that HAC could be used to support bone growth adjacent to dental implants placed in immediate tooth extraction sites. Variable levels of bone contact were noted up to 3 months postimplantation. Considerable loss of HAC occurred and was thought to be because of "washout" of the cement before complete cement setting. When HAC was immobile in the surgical site, the bioactive nature of the cement led to HAC resorption and bone deposition. Efforts to maintain the HAC in situ should be expanded so that the full clinical potential of the HAC can be realized.
基于磷酸钙化学的生物活性骨水泥已被开发用作骨替代材料。一种这样的商业产品，即骨源（BoneSource），是一种用于颅面复合体小骨缺损的羟基磷灰石骨水泥（HAC）。我们研究了HAC用于支持紧邻即刻拔牙位点植入的牙种植体周围骨生长的可能性。植入后3个月内观察到不同程度的骨接触。HAC发生了相当程度的流失，被认为是由于水泥在完全凝固前被“冲洗掉”。当HAC在手术部位固定不动时，骨水泥的生物活性导致HAC吸收和骨沉积。应加大力度将HAC原位固定，以便充分发挥HAC的临床潜力。
