Marriott C, Kellaway I W
J Pharm Pharmacol. 1976 Aug;28(8):620-4. doi: 10.1111/j.2042-7158.1976.tb02813.x.
The goldfish has been used as a model membrane to estimate the absorption of quinalbarbitone sodium by measurement of overturn time. The effect of sodium cholate, sodium deoxycholate, sodium chenodeoxycholate and sodium taurodeoxycholate on the quinalbarbitone-induced overturn time has been investigated and differences in capacity to promote absorption have been demonstrated. These differences could not be attributed to variations in solubility or partitioning of the drug within the membrane by the bile salts or to the relative hydrophobicity of each molecule. It is suggested that the bile salts must in someway affect the integrity of the goldfish membrane rendering it more permeable to quinalbarbitone sodium.
金鱼已被用作模型膜，通过测量翻转时间来估计硫喷妥钠的吸收情况。研究了胆酸钠、脱氧胆酸钠、鹅去氧胆酸钠和牛磺脱氧胆酸钠对硫喷妥钠诱导的翻转时间的影响，并证明了它们促进吸收能力的差异。这些差异不能归因于胆汁盐对药物在膜内溶解度或分配的影响，也不能归因于每个分子的相对疏水性。有人提出，胆汁盐必定以某种方式影响金鱼膜的完整性，使其对硫喷妥钠更具渗透性。
