Bennett A, Carter R L, Stamford I F, Tanner N S
Br J Cancer. 1980 Feb;41(2):204-8. doi: 10.1038/bjc.1980.31.
Tumour-associated prostaglandin-like material, assessed by bioassay, has been examined in 37 patients with primary and metastatic squamous carcinomas of the head and neck, previously treated by radiotherapy and chemotherapy followed by radical surgery. High amounts of prostaglandin-like material were extracted from tumours excised within 3 months of radiotherapy and chemotherapy. These amounts correlated with necrosis, inflammation and fibrosis, but not with tumour site, size or degree of differentiation. Most of the prostaglandins formed by these treated tumours thus seem to be associated with host stromal and inflammatory cells, rather than the neoplastic cells. The possible roles of prostaglandins in facilitating the spread of squamous carcinomas are discussed.
通过生物测定评估的肿瘤相关前列腺素样物质，已在37例头颈部原发性和转移性鳞状癌患者中进行了检测，这些患者先前接受过放疗和化疗，随后接受了根治性手术。在放疗和化疗后3个月内切除的肿瘤中提取到了大量的前列腺素样物质。这些量与坏死、炎症和纤维化相关，但与肿瘤部位、大小或分化程度无关。因此，这些经治疗的肿瘤形成的大多数前列腺素似乎与宿主基质和炎性细胞有关，而非与肿瘤细胞有关。本文讨论了前列腺素在促进鳞状癌扩散中的可能作用。
