Konermann M, Radü B, Liebetrau M, Rawert B, Heimbucher J, Sanner B M
Medizinischen Klinik des Marienkrankenhauses Kassel, Deutschland.
Wien Med Wochenschr. 1999;151(5-6):142-6.
Chronic laryngitis is a common disease with a multifactoral genesis. One of the known causal factors is gastrolaryngeal acid reflux as a consequence of gastroesophageal reflux disease (GERD). 10 to 30% of the patients do not show an adequate response to the standard treatment with proton pump inhibitors, which could not be well explained in the past. Our own observations indicate, that sleep related gastroesophageal reflux may play an important role. The special physiological conditions in sleep can impair the reflux, and an increased nocturnal breathing effort in snoring or sleep apnea induces an intensive gastrolaryngeal reflux. This paper explains the pathophysiological background and the diagnostics and differential treatment.
慢性喉炎是一种病因多因素的常见疾病。已知的致病因素之一是胃食管反流病（GERD）导致的胃喉反流。10%至30%的患者对质子泵抑制剂的标准治疗没有充分反应，这在过去无法得到很好的解释。我们自己的观察表明，与睡眠相关的胃食管反流可能起重要作用。睡眠中的特殊生理状况会损害反流，打鼾或睡眠呼吸暂停时夜间呼吸努力增加会导致强烈的胃喉反流。本文解释了其病理生理背景、诊断及鉴别治疗。
