Uehara Y, Kikuchi K, Nakamura T, Nakama H, Agematsu K, Kawakami Y, Maruchi N, Totsuka K
Division of Clinical Pathology, Nagano Children's Hospital, Toyoshina, Japan.
Clin Infect Dis. 2001 May 15;32(10):1399-407. doi: 10.1086/320147. Epub 2001 Apr 17.
We investigated the role of viridans group streptococci in the prevention of colonization with methicillin-resistant Staphylococcus aureus (MRSA) in neonatal intensive care units. During a 26-month period at a children's hospital, 207 (49.9%) of 415 newborns were colonized with MRSA by the time of discharge. Two groups of newborns with matching durations of hospitalization were compared with regard to the prevalence of future colonization with MRSA: group 1 (103 patients) did not acquire colonization with viridans group streptococci and group 2 (63 patients) did acquire colonization with viridans group streptococci at birth or by 1 to 2 weeks (age, < or =11 days). The rate of colonization among patients in group 2 (9.5%) was significantly lower than that among patients in group 1 (44.7%; P<.001). No significant difference in patient characteristics (e.g., birth weight, diseases) was observed. These results indicate that viridans group streptococci, as bacteria that formerly occupied the oral cavities in newborns, may inhibit later colonization with MRSA.
我们调查了草绿色链球菌在新生儿重症监护病房预防耐甲氧西林金黄色葡萄球菌（MRSA）定植中的作用。在一家儿童医院为期26个月的时间里，415名新生儿中有207名（49.9%）在出院时被MRSA定植。比较了两组住院时间匹配的新生儿未来MRSA定植的患病率：第1组（103例患者）未获得草绿色链球菌定植，第2组（63例患者）在出生时或1至2周（年龄≤11天）获得了草绿色链球菌定植。第2组患者的定植率（9.5%）显著低于第1组患者（44.7%；P<0.001）。未观察到患者特征（如出生体重、疾病）的显著差异。这些结果表明，草绿色链球菌作为以前占据新生儿口腔的细菌，可能会抑制后来MRSA的定植。
