Yoshida K, Hamajima N, Saito H, Maeno K, Sugiura T, Ookuma K, Takahashi T
Department of Pulmonary Medicine, Aichi Cancer Center Hospital, Chikusa-ku, Nagoya, Japan.
Cancer Epidemiol Biomarkers Prev. 2001 Apr;10(4):403-5.
For the study presented here, we investigated possible links between the dopamine D2 receptor (DRD2) TaqIA genotype (DRD2A) and smoking behavior in a total of 332 Japanese individuals. For the first time, functional insertion/deletion polymorphism (-141C Ins/Del) in the DRD2 promoter was also examined in relation to smoking behavior. The distribution of the DRD2A genotype was significantly different among current, former, and never-smokers (P = 0.001; chi(2) test), and smoking appeared to be associated with the DRD2 A2/A2 genotype, showing marked contrast to previous reports for non-Hispanic whites in the United STATES: Multivariate logistic regression analysis incorporating age, sex, genotype, and smoking status as variables revealed that DRD2 A2/A2 genotype was significantly associated with an increased risk of predisposition to smoking behavior in the Japanese (odds ratio, 3.680; 95% confidence interval, 1.499-9.052). In contrast, such an increased risk was not observed in terms of association with the -141C Ins/Del polymorphism. These findings suggest an association of the DRD2*A genotype with an increased risk of being predisposed to smoking behavior in the Japanese and suggest the possible existence of ethnic group-specific differences, which warrant additional studies on the underlying molecular mechanism.
在此项研究中，我们调查了332名日本个体中多巴胺D2受体（DRD2）TaqIA基因型（DRD2A）与吸烟行为之间可能存在的联系。首次还研究了DRD2启动子中的功能性插入/缺失多态性（-141C Ins/Del）与吸烟行为的关系。DRD2A基因型的分布在当前吸烟者、既往吸烟者和从不吸烟者中存在显著差异（P = 0.001；卡方检验），并且吸烟似乎与DRD2 A2/A2基因型相关，这与美国非西班牙裔白人的先前报道形成鲜明对比：将年龄、性别、基因型和吸烟状况作为变量纳入的多变量逻辑回归分析显示，DRD2 A2/A2基因型与日本人吸烟行为易感性增加的风险显著相关（优势比，3.680；95%置信区间，1.499 - 9.052）。相比之下，未观察到与-141C Ins/Del多态性相关的这种风险增加。这些发现表明DRD2*A基因型与日本人吸烟行为易感性增加的风险相关，并提示可能存在种族特异性差异，这需要对潜在的分子机制进行更多研究。
