Franz C, Longcope C
Endocrinology. 1979 Oct;105(4):869-74. doi: 10.1210/endo-105-4-869.
Using constant infusions of 3H-labeled androgens and 14C-labeled estrogens, the dynamics of androgen and estrogen metabolism have been studied in male rhesus monkeys. The mean (+/-) MCR, as measured in whole blood, for testosterone (T; 140 +/- 10 liters/day) was significantly smaller than the MCRs for androstenedione (A), estrone (E1), and estradiol (E2; 650 +/- 8, 1010 +/- 160, and 500 +/- 20 liters/day, respectively). These findings are compatible with the specific globulin binding of T in this species. The mean blood productions were 0.42 +/- 0.11 and 0.55 +/- 0.04 mg/day for A and T and 40 +/- 16 and 13 +/- micrograms/day for E1 and E2, respectively. The interconversions of the androgens [fractional conversion rates of A to T ([rho]A,TBB) and T to A ([rho]T,ABB)] were not different but were lower than the interconversions of the estrogens ([rho]E1,E2BB and [rho]E2,E1BB). The mean [rho]T,E2BB values were 0.015 +/- 0.001 and 0.0024 +/- 0.0003, which are remarkably similiar to those values in men. Administrations of PMS gonadotropin did not alter any measured values of androgen or estrogen metabolism, hCG resulted in a decrease in the conversion ratio of A to T, T administration increased the MCR of T, and estrogen administration resulted in no changes. The aromatization rate remained unaffected by all treatments.
通过持续输注³H标记的雄激素和¹⁴C标记的雌激素，对雄性恒河猴体内雄激素和雌激素的代谢动态进行了研究。以全血测量的睾酮（T；140±10升/天）的平均（±）代谢清除率（MCR）显著低于雄烯二酮（A）、雌酮（E1）和雌二醇（E2；分别为650±8、1010±160和500±20升/天）的MCR。这些发现与该物种中T的特异性球蛋白结合情况相符。A和T的平均血液生成量分别为0.42±0.11和0.55±0.04毫克/天，E1和E2的平均血液生成量分别为40±16和13±微克/天。雄激素的相互转化[A转化为T的分数转化率（ρA，TBB）和T转化为A的分数转化率（ρT，ABB）]没有差异，但低于雌激素的相互转化（ρE1，E2BB和ρE2，E1BB）。平均ρT，E2BB值分别为0.015±0.001和0.0024±0.0003，与男性中的值非常相似。注射孕马血清促性腺激素不会改变雄激素或雌激素代谢的任何测量值，注射人绒毛膜促性腺激素会导致A转化为T的转化率降低，注射T会增加T的MCR，而注射雌激素则不会导致变化。所有处理均未影响芳香化速率。
