Longcope C, Baker S
Department of Obstetrics and Gynecology, University of Massachusetts Medical School, Worcester 01655.
J Clin Endocrinol Metab. 1993 Mar;76(3):601-4. doi: 10.1210/jcem.76.3.8445016.
Previous studies have shown a relationship between age and weight and the MCR and conversions ([rho]) of androgens and estrogens. To assess the relative importance of these relationships in the metabolism and conversion of the androgens and estrogens, we used a series of statistical analyses, including t test, Pearson's correlation, and a step-wise regression analysis of the data obtained from the constant infusion of radiolabeled androgens and estrogens to normal women, 18-90 yr old. The MCRs of testosterone (T), androstenedione (A), and estrone (E1) were strongly correlated with weight, but not age or menopausal status. The MCR of estradiol (E2) was strongly correlated with weight and less strongly correlated with age, but was not correlated with menopausal status. The interconversions of the androgens ([rho]T,ABB and [rho]A,TBB, i.e. percentage of precursor infused measured as product in blood) and estrogens ([rho]E1,E2BB and [rho]E2,E1BB) were not correlated with age or weight, but there was a weak correlation between [rho]T,ABB and menopausal status. The aromatization of androgens to estrogens ([rho] A,E1BM and [rho]T,E2BM, i.e. percentage of androgens infused measured as estrogen glucuronide in the urine) was highly correlated with age, less strongly correlated with weight, and not correlated with menopausal status. The correlation with weight and MCR is a reflection of the extrasplanchnic metabolism of steroids. The lack of correlation with weight for the interconversions of androgens and estrogens indicates that the enzyme(s) responsible is affected differently in extrasplanchnic tissue than is the aromatase complex. The relationship between age and aromatization, while strong, remains unexplained.
以往的研究表明，年龄、体重与雄激素和雌激素的代谢清除率（MCR）以及转化率（[rho]）之间存在关联。为了评估这些关系在雄激素和雌激素代谢及转化中的相对重要性，我们进行了一系列统计分析，包括t检验、Pearson相关性分析，以及对18至90岁正常女性持续输注放射性标记雄激素和雌激素所获得数据的逐步回归分析。睾酮（T）、雄烯二酮（A）和雌酮（E1）的MCR与体重密切相关，但与年龄或绝经状态无关。雌二醇（E2）的MCR与体重密切相关，与年龄的相关性较弱，但与绝经状态无关。雄激素的相互转化（[rho]T,ABB和[rho]A,TBB，即输注的前体在血液中作为产物测量的百分比）和雌激素的相互转化（[rho]E1,E2BB和[rho]E2,E1BB）与年龄或体重无关，但[rho]T,ABB与绝经状态之间存在微弱关联。雄激素向雌激素的芳香化作用（[rho] A,E1BM和[rho]T,E2BM，即输注的雄激素在尿液中作为雌激素葡萄糖醛酸测量的百分比）与年龄高度相关，与体重的相关性较弱，与绝经状态无关。与体重和MCR的相关性反映了类固醇的肝外代谢情况。雄激素和雌激素相互转化与体重缺乏相关性表明，负责该转化的酶在肝外组织中的受影响方式与芳香化酶复合物不同。年龄与芳香化作用之间的关系虽然密切，但仍无法解释。
