Longcope C, Baker R, Johnston C C
Metabolism. 1986 Mar;35(3):235-7. doi: 10.1016/0026-0495(86)90206-4.
Adipose tissue contains both aromatase and 17 beta-steroid dehydrogenase activity. Therefore, to see whether there was a relationship between obesity and certain parameters of androgen and estrogen metabolism we infused 88 women, mean age 51.1 +/- 0.3 years and mean weight 140 +/- 3 lbs, with 3H-testosterone (T)/14C-estradiol (E2) and 3H-androstenedione (A)/14C-estrone (E1) on separate occasions. Blood samples were obtained during the infusion and all urine was collected for 4 days following the start of the infusion. The blood samples were analyzed for radioactivity as A, T, E1, E2, and dihydrotestosterone (DHT) and the urines were analyzed for radioactivity as E1 and E2. From these data we calculated the percent of A converted to T ([rho]A,TBB = percent of A infused measured as T in the blood), [rho]T,ABB [rho]E1,E2BB, and [rho]E2,E1BB. We also measured the ratio of radioactivity as 3H-DHT to radioactivity as 3H-A (CRA,DHT) and 3H-T (CRT,DHT) during the respective androgen infusions. From the ratio of 3H/14C as estrone or estradiol in the urine following 3H-A or 3H-T infusions, we calculated the percent of A or T that was aromatized to E1 or E2 ([rho]A,E1BM; [rho]T,E2BM). When the data from these women were related to weight or Quetelet's Index (QI = wt/ht2) by unweighted linear regression, the only values that were significantly correlated with weight and QI were [rho]T,E2BM and [rho]A,E1BM; for all other [rho] and CR values there was no correlation with weight or QI. We conclude that peripheral aromatization is positively correlated with adiposity but androgen interconversions and estrogen interconversions are not related to adiposity.
脂肪组织同时具备芳香化酶和17β - 类固醇脱氢酶活性。因此，为了探究肥胖与雄激素和雌激素代谢某些参数之间是否存在关联，我们对88名女性进行了研究，她们的平均年龄为51.1±0.3岁，平均体重为140±3磅，分别在不同时间点注入3H - 睾酮（T）/14C - 雌二醇（E2）以及3H - 雄烯二酮（A）/14C - 雌酮（E1）。在注入过程中采集血样，并在注入开始后的4天内收集所有尿液。对血样进行放射性分析，检测其中的A、T、E1、E2和双氢睾酮（DHT），对尿液进行放射性分析，检测其中的E1和E2。根据这些数据，我们计算了A转化为T的百分比（[rho]A,TBB = 注入的A中以血液中的T形式测得的百分比）、[rho]T,ABB、[rho]E1,E2BB和[rho]E2,E1BB。我们还在各自的雄激素注入过程中测量了3H - DHT的放射性与3H - A（CRA,DHT）和3H - T（CRT,DHT）的放射性之比。根据注入3H - A或3H - T后尿液中雌酮或雌二醇的3H/14C比值，我们计算了A或T芳香化为E1或E2的百分比（[rho]A,E1BM；[rho]T,E2BM）。当通过未加权线性回归将这些女性的数据与体重或奎特列指数（QI = 体重/身高²）相关联时，唯一与体重和QI显著相关的值是[rho]T,E2BM和[rho]A,E1BM；对于所有其他的[rho]和CR值，与体重或QI均无相关性。我们得出结论，外周芳香化作用与肥胖呈正相关，但雄激素相互转化和雌激素相互转化与肥胖无关。
