Pedley T A, Horton R W, Meldrum B S
Epilepsia. 1979 Aug;20(4):409-16. doi: 10.1111/j.1528-1157.1979.tb04821.x.
Muscimol, 0.25-1.0 mg/kg, i.v., was administered acutely to 4 adolescent baboons, Papio papio, that show photically induced epilepsy. On the EEG, slowing of background rhythms was associated with the appearance of spikes, polyspikes, and recurring symmetrical spike-wave complexes. These changes were maximal 0.5-2 hr after muscimol injection. Regular testing with intermittent light stimulation showed either no change from control responses or a more severe epileptiform EEG 0.1-3 hr after muscimol. Photically induced myoclonus was not modified by muscimol. Despite its GABA-abonist properties, muscimol is not an effective anticonvulsant.
对4只表现出光诱发性癫痫的未成年狒狒（豚尾狒狒）急性静脉注射0.25 - 1.0毫克/千克的蝇蕈醇。脑电图显示，背景节律减慢与棘波、多棘波和反复出现的对称棘慢复合波的出现有关。这些变化在注射蝇蕈醇后0.5 - 2小时最为明显。间歇性光刺激的定期测试显示，与对照反应相比无变化，或在注射蝇蕈醇后0.1 - 3小时脑电图癫痫样表现更严重。蝇蕈醇并未改变光诱发性肌阵挛。尽管蝇蕈醇具有GABA激动剂特性，但它并不是一种有效的抗惊厥药。
