Sayers S P, Knight C A, Clarkson P M, Van Wegen E H, Kamen G
Department of Exercise Science, University of Massachusetts, Amherst, MA 01003, USA.
Med Sci Sports Exerc. 2001 May;33(5):702-10. doi: 10.1097/00005768-200105000-00004.
This study examined whether ketoprofen, a nonsteroidal anti-inflammatory drug, attenuated muscle soreness (SOR), improved maximal isometric force (MIF) recovery, and/or altered myoelectric activity after high-force eccentric exercise.
48 subjects were randomly assigned to one of four groups: CON: no exercise/no drug (N = 12); PLA: exercise + placebo (N = 12); TRT-100: exercise + 100 mg oral ketoprofen (N = 12); and TRT-25: exercise + 25 mg oral ketoprofen (N = 12). PLA, TRT-100, and TRT-25 were administered in a double-blind fashion. Baseline measurements of SOR, MIF, and surface electromyographic (EMG) amplitude were taken, and PLA, TRT-100, and TRT-25 performed 50 maximal eccentric contractions of the elbow flexors; 36 h later, subjects reporting moderate soreness were given ketoprofen or placebo and SOR measures were taken hourly for 8 h. EMG amplitude was assessed during MIF before dosing and again 8 h later and during submaximal contractions of 5%, 10%, and 20% of MIF before dosing and hourly for 8 h.
Eccentric exercise increased myoelectric activity during submaximal force measurements in PLA, TRT-100, and TRT-25 in all conditions. Ketoprofen had no effect on reducing this increase in EMG activity. Ketoprofen attenuated perceived SOR (P < 0.05) and enhanced MIF recovery (P < 0.05) compared with placebo. TRT-100 and TRT-25 demonstrated 10% and 19% reductions in SOR, respectively, and 16% and 9% increases in MIF, respectively, whereas PLA demonstrated a 1% increase in SOR and 9% decrease in MIF over 8 h.
Ketoprofen treatment after muscle damaging exercise reduces muscle soreness and improves force recovery.
本研究旨在探讨非甾体抗炎药酮洛芬是否能减轻肌肉酸痛（SOR）、改善最大等长肌力（MIF）恢复，和/或改变高强度离心运动后的肌电活动。
48名受试者被随机分为四组之一：对照组：不运动/不服用药物（N = 12）；安慰剂组：运动+安慰剂（N = 12）；TRT - 100组：运动+ 100毫克口服酮洛芬（N = 12）；TRT - 25组：运动+ 25毫克口服酮洛芬（N = 12）。安慰剂组、TRT - 100组和TRT - 25组采用双盲给药方式。对SOR、MIF和表面肌电图（EMG）振幅进行基线测量，安慰剂组、TRT - 100组和TRT - 25组进行50次肘部屈肌最大离心收缩；36小时后，报告有中度酸痛的受试者服用酮洛芬或安慰剂，并每小时进行一次SOR测量，持续8小时。在给药前和给药8小时后进行MIF期间评估EMG振幅，在给药前进行5%、10%和20% MIF的次最大收缩期间以及每小时进行一次，持续8小时。
在所有情况下，离心运动均增加了安慰剂组、TRT - 100组和TRT - 25组次最大力量测量期间的肌电活动。酮洛芬对减少这种EMG活动增加没有作用。与安慰剂相比，酮洛芬减轻了感知到的SOR（P < 0.05）并增强了MIF恢复（P < 0.05）。TRT - 100组和TRT - 25组的SOR分别降低了10%和19%，MIF分别增加了16%和9%，而安慰剂组在8小时内SOR增加了1%，MIF降低了9%。
肌肉损伤运动后服用酮洛芬可减轻肌肉酸痛并改善力量恢复。
