Leahy Danielle T, Pintauro Stephen J
Department of Nutrition and Food Sciences, University of Vermont, Burlington, VT 05405, USA.
ISRN Nutr. 2013 Mar 17;2013:921972. doi: 10.5402/2013/921972. eCollection 2013.
Supplementation with branched-chain amino acids (BCAAs) has been used to stimulate muscle protein synthesis following exercise. The purpose of this study was to determine if supplementation with BCAAs in combination with glucose would reduce exercise-induced delayed onset muscle soreness (DOMS). Using a double-blind crossover design, 20 subjects (11 females, 9 males) were randomly assigned to either BCAA (n = 10) or placebo (n = 10) groups. Subjects performed a squatting exercise to elicit DOMS and rated their muscle soreness every 24 hours for four days following exercise while continuing to consume the BCAA or placebo. Following a three-week recovery period, subjects returned and received the alternate BCAA or placebo treatment, repeating the same exercise and DOMS rating protocol for the next four days. BCAA supplementation in female subjects resulted in a significant decrease in DOMS versus placebo at 24 hours following exercise (P = 0.018). No significant effect of BCAA supplementation versus placebo was noted in male subjects nor when male and female results were analyzed together. This gender difference may be related to dose per body weight differences between male and female subjects.
补充支链氨基酸（BCAAs）已被用于在运动后刺激肌肉蛋白质合成。本研究的目的是确定补充BCAAs与葡萄糖联合使用是否会减轻运动诱导的延迟性肌肉酸痛（DOMS）。采用双盲交叉设计，将20名受试者（11名女性，9名男性）随机分为BCAA组（n = 10）或安慰剂组（n = 10）。受试者进行深蹲运动以引发DOMS，并在运动后的四天内每24小时对肌肉酸痛进行评分，同时继续服用BCAA或安慰剂。在为期三周的恢复期后，受试者返回并接受交替的BCAA或安慰剂治疗，在接下来的四天内重复相同的运动和DOMS评分方案。在运动后24小时，女性受试者补充BCAA导致DOMS较安慰剂组显著降低（P = 0.018）。在男性受试者中，以及在将男性和女性结果一起分析时，未观察到补充BCAA与安慰剂之间的显著差异。这种性别差异可能与男性和女性受试者每体重剂量差异有关。
