Robinson B W, Robinson C, Lake R A
University Department of Medicine, University of Western Australia, Sir Charles Gairdner Hospital, G Block, 4th Floor, Monash Avenue, 6009, Nedlands, Australia.
Lung Cancer. 2001 May;32(2):197-201. doi: 10.1016/s0169-5002(00)00217-8.
Malignant mesothelioma (MM) is an aggressive tumor usually associated with asbestos exposure. Although it can remain stable for prolonged periods, it has not been described to spontaneously regress. MM tumors are thought to be immunogenic based both on animal studies and on the good responses in some humans treated with immunotherapy. Here we present a case of pleural MM in which a transient spontaneous regression was associated with tumor tissue infiltration with mononuclear cells and serological evidence of anti-MM reactivity. The patient's tumor eventually progressed and with this progression there was evidence of loss of serological reactivity to some, but not all, of her MM antigens. The patient survived for 20 months and, in contrast to her initial biopsy, no significant lymphoid infiltrate was detected in her MM tissue at post mortem examination.
恶性间皮瘤（MM）是一种侵袭性肿瘤，通常与接触石棉有关。尽管它可以长期保持稳定，但尚未有自发消退的报道。基于动物研究以及一些接受免疫治疗的患者的良好反应，MM肿瘤被认为具有免疫原性。在此，我们报告一例胸膜MM病例，其中短暂的自发消退与肿瘤组织单核细胞浸润以及抗MM反应性的血清学证据相关。患者的肿瘤最终进展，随着进展，有证据表明其对部分（而非全部）MM抗原的血清学反应性丧失。患者存活了20个月，与最初的活检结果相反，尸检时在其MM组织中未检测到明显的淋巴细胞浸润。
