Robinson Bruce W S, Redwood Alec J, Creaney Jenette
Medicine, University of Western Australia, Perth, WA, Australia.
Institute for Respiratory Health, University of Western Australia, Perth, WA, Australia.
Front Pharmacol. 2022 Mar 31;13:858557. doi: 10.3389/fphar.2022.858557. eCollection 2022.
Asbestos-induced preclinical mouse models of mesothelioma produce tumors that are very similar to those that develop in humans and thus represent an ideal platform to study this rare, universally fatal tumor type. Our team and a number of other research groups have established such models as a stepping stone to new treatments, including chemotherapy, immunotherapy and other approaches that have been/are being translated into clinical trials. In some cases this work has led to changes in mesothelioma treatment practice and over the last 30 years these models and studies have led to trials which have improved the response rate in mesothelioma from less than 10% to over 50%. Mouse models have had a vital role in that improvement and will continue to play a key role in the future success of mesothelioma immunotherapy. In this review we focus only on these original inbred mouse models, the large number of preclinical studies conducted using them and their contribution to current and future clinical therapy for mesothelioma.
石棉诱发的间皮瘤临床前小鼠模型所产生的肿瘤与人类发生的肿瘤非常相似，因此是研究这种罕见的、普遍致命的肿瘤类型的理想平台。我们的团队和其他一些研究小组已经建立了这样的模型，作为通向新治疗方法的垫脚石，这些新治疗方法包括化疗、免疫疗法以及其他已经/正在转化为临床试验的方法。在某些情况下，这项工作已经导致间皮瘤治疗实践的改变，在过去30年里，这些模型和研究已经促成了一些试验，这些试验使间皮瘤的缓解率从不到10%提高到了50%以上。小鼠模型在这一改善过程中发挥了至关重要的作用，并将继续在间皮瘤免疫疗法未来的成功中发挥关键作用。在这篇综述中，我们仅关注这些原始的近交系小鼠模型、使用它们进行的大量临床前研究以及它们对当前和未来间皮瘤临床治疗的贡献。
