D'Hooghe T M, Xiao L, Hill J A
Leuven University Fertility Center, Department of Obstetrics and Gynecology, University Hospital Gasthuisberg, Belgium.
Arch Gynecol Obstet. 2001 Mar;265(1):40-4. doi: 10.1007/s004040000126.
In a preliminary study the hypothesis was tested that cytokine profiles in peripheral blood were higher in women with deep infiltrating endometriosis and cytokine profiles in peritoneal fluid were higher in women with superficial endometriosis. Thirteen women of reproductive age having laparoscopy for infertility (n=9), pain (n=3) or combined pain and infertility (n=1). Peripheral blood and peritoneal fluid were obtained and analyzed for Interleukin-6 (IL-6), Tumor Necrosis Factor-alpha (TNF-alpha), Interleukin-10 (IL-10), Transforming Growth Factor-betal (TGFbeta1), and Interferon-gamma (IFN-gamma). No significant cytokine differences were observed in either peritoneal fluid or peripheral blood between IL-6, TGFbeta1, IFNgamma, TNF-alpha and IL-10 of women with superficial endometriosis (n=7) and women with deeply infiltrating endometriosis (n=6). The results of this preliminary study do not show significant differences in peripheral blood and peritoneal fluid cytokine levels between women with deep infiltrating endometriosis compared to women with superficial disease. Future studies with increased sample size are required to either confirm or refute these preliminary findings.
在一项初步研究中，对以下假设进行了检验：深部浸润性子宫内膜异位症女性外周血中的细胞因子谱更高，而浅表性子宫内膜异位症女性腹腔液中的细胞因子谱更高。13名育龄期女性因不孕症（n = 9）、疼痛（n = 3）或疼痛合并不孕症（n = 1）接受了腹腔镜检查。采集外周血和腹腔液，并分析其中白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）、白细胞介素-10（IL-10）、转化生长因子-β1（TGFβ1）和干扰素-γ（IFN-γ）的水平。在浅表性子宫内膜异位症女性（n = 7）和深部浸润性子宫内膜异位症女性（n = 6）的腹腔液或外周血中，未观察到IL-6、TGFβ1、IFNγ、TNF-α和IL-10之间存在显著的细胞因子差异。这项初步研究的结果并未显示深部浸润性子宫内膜异位症女性与浅表性疾病女性在外周血和腹腔液细胞因子水平上存在显著差异。需要进一步开展样本量更大的研究来证实或反驳这些初步发现。
