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静脉输注前列腺素E-2和F-2α对人体胃功能的影响。

The effect of intravenous infusions of prostaglandins E-2 and F-2alpha on human gastric function.

作者信息

Newman A, de Moraes-Filho J P, Philippakos D, Misiewicz J J

出版信息

Gut. 1975 Apr;16(4):272-6. doi: 10.1136/gut.16.4.272.

DOI:10.1136/gut.16.4.272
PMID:1132802
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1410922/
Abstract

The effect of intravenous infusions of prostaglandins E-2 and F(-2alpha) at various dose levels on basal, or on maximally or submaximally pentagastrin-stimulated acid secretion, was studied in 40 male subjects. Intraluminal antral pressures were also measured. Prostaglandin F (0.08 mug kg-minus 1 min-minus 1) transiently, but significantly, inhibited submaximal acid output and increased the frequency of antral contractions. Prostaglandin E(2)(0.08 mug kg-minus 1 min-minus 1) inhibited basal acid secretion.

摘要

在40名男性受试者中研究了不同剂量水平的前列腺素E-2和F（-2α）静脉输注对基础胃酸分泌、最大或次最大五肽胃泌素刺激的胃酸分泌的影响。还测量了腔内胃窦压力。前列腺素F（0.08微克/千克·分钟-1分钟-1）短暂但显著地抑制了次最大胃酸分泌，并增加了胃窦收缩频率。前列腺素E2（0.08微克/千克·分钟-1分钟-1）抑制基础胃酸分泌。

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本文引用的文献

1
A COMPARISON OF THE ACTIONS OF PROSTAGLANDINS F2-ALPHA AND E1 ON SMOOTH MUSCLE.前列腺素F2-α与E1对平滑肌作用的比较
Br J Pharmacol Chemother. 1965 Apr;24(2):470-6. doi: 10.1111/j.1476-5381.1965.tb01736.x.
2
EFFECTS OF THE PROSTAGLANDINS ON HORMONE-INDUCED MOBILIZATION OF FREE FATTY ACIDS.前列腺素对激素诱导的游离脂肪酸动员的影响。
J Clin Invest. 1964 Aug;43(8):1533-40. doi: 10.1172/JCI105030.
3
Occurrence of prostaglandin E2 in the human stomach, and a study of its effects on human isolated gastric muscle.前列腺素E2在人胃中的出现及其对人离体胃肌作用的研究。
Br J Pharmacol Chemother. 1968;32(2):339-49.
4
Motor responses of the human alimentary tract to near-maximal infusions of pentagastrin.人体消化道对近最大剂量五肽胃泌素输注的运动反应。
Gut. 1967 Oct;8(5):463-9. doi: 10.1136/gut.8.5.463.
5
Effects of prostaglandins E1 and E2 on human, guinea-pig and rat isolated small intestine.前列腺素E1和E2对人、豚鼠及大鼠离体小肠的作用。
Br J Pharmacol. 1968 Nov;34(3):630-8. doi: 10.1111/j.1476-5381.1968.tb08492.x.
6
Cardiovascular responses to intracoronary infusion of prostaglandin E-1, F-1 alpha and F-2 alpha.冠状动脉内注入前列腺素E-1、F-1α和F-2α后的心血管反应。
Arch Int Pharmacodyn Ther. 1968 Jul;174(1):66-73.
7
Response of the electrical activity, motor activity and acid secretion of the human stomach to pentagastrin and histamine stimulation.人胃的电活动、运动活动及胃酸分泌对五肽胃泌素和组胺刺激的反应。
Scand J Gastroenterol. 1971;6(2):145-53. doi: 10.3109/00365527109180684.
8
[Effect of prostaglandin E 1 on the basal gastric secretion in man].[前列腺素E1对人体基础胃分泌的影响]
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9
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Gastroenterology. 1972 Jul;63(1):60-6.
10
The effect of prostaglandin E 1 on canine gastric acid secretion and gastric mucosal blood flow.前列腺素E1对犬胃酸分泌及胃黏膜血流的影响。
Am J Dig Dis. 1972 Jun;17(6):527-32. doi: 10.1007/BF02231209.