静脉输注前列腺素E-2和F-2α对人体胃功能的影响。
The effect of intravenous infusions of prostaglandins E-2 and F-2alpha on human gastric function.
作者信息
Newman A, de Moraes-Filho J P, Philippakos D, Misiewicz J J
出版信息
Gut. 1975 Apr;16(4):272-6. doi: 10.1136/gut.16.4.272.
Abstract
The effect of intravenous infusions of prostaglandins E-2 and F(-2alpha) at various dose levels on basal, or on maximally or submaximally pentagastrin-stimulated acid secretion, was studied in 40 male subjects. Intraluminal antral pressures were also measured. Prostaglandin F (0.08 mug kg-minus 1 min-minus 1) transiently, but significantly, inhibited submaximal acid output and increased the frequency of antral contractions. Prostaglandin E(2)(0.08 mug kg-minus 1 min-minus 1) inhibited basal acid secretion.
摘要
在40名男性受试者中研究了不同剂量水平的前列腺素E-2和F（-2α）静脉输注对基础胃酸分泌、最大或次最大五肽胃泌素刺激的胃酸分泌的影响。还测量了腔内胃窦压力。前列腺素F（0.08微克/千克·分钟-1分钟-1）短暂但显著地抑制了次最大胃酸分泌，并增加了胃窦收缩频率。前列腺素E2（0.08微克/千克·分钟-1分钟-1）抑制基础胃酸分泌。
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