腹内侧下丘脑神经化学机制在大鼠各种焦虑模型中的作用。

The role of neurochemical mechanisms of ventromedial hypothalamus in various models of anxiety in rats.

作者信息

Talalaenko A N, Gordienko D V, Pankrat'ev D V, Zinkovich I I, Krivobok G K

机构信息

Department of Pharmacology; Laboratory of Behavioral Physiology and Pharmacology, Central Research Laboratory of M. Gor'kii State Medical University, Donetsk.

出版信息

Bull Exp Biol Med. 2001 Jan;131(1):38-40. doi: 10.1023/a:1017574427957.

DOI:10.1023/a:1017574427957

PMID:11329078

Abstract

Microinjections of glutamic acid, serotonin, and sulpiride in the ventromedial hypothalamus reduced anxiety in an illuminated platform avoidance task in rats, while dopamine, apomorphine, picrotoxin, and memantine increased it. Similar injections of phenylephrine and yohimbine reduced anxiety in threatening situation task only, while GABA reduced it in both tasks. It is suggested that various emotional and stress phenotypes are realized through functionally different neurochemical mechanisms of ventromedial hypothalamus.

摘要

在下丘脑腹内侧微量注射谷氨酸、血清素和舒必利可降低大鼠在光照平台回避任务中的焦虑，而多巴胺、阿扑吗啡、印防己毒素和美金刚则会增加焦虑。在威胁情境任务中，类似地注射去氧肾上腺素和育亨宾只会降低焦虑，而γ-氨基丁酸在两项任务中均能降低焦虑。这表明，下丘脑腹内侧不同的神经化学机制可实现各种情绪和应激表型。