[蓝斑单胺能和氨基酸能机制在不同厌恶源所致焦虑中的功能作用]

[The functional role of monoaminergic and amino acid-ergic mechanisms of the locus coeruleus in anxiety from different aversive origins].

作者信息

Talalaenko A N, Stakhovskiĭ Iu V, Bogdanov B A, Babiĭ Iu V, Perch N N

出版信息

Biull Eksp Biol Med. 1993 Jun;115(6):634-6.

Abstract

Dopamine and glutamine acid microinjection in the locus coeruleus of rats does not influence the alarm state in the test of "Threatening situation" avoidance, but weakens the state of alarm in the test of "illuminated site" avoidance. The local injection of GABA and noradrenaline mesatone effect imitators in this brain formation weakens the alarm state in the test of "threatening situation" avoidance but is not effective in the test of "illuminated site" avoidance. On the contrary, the chemical stimulation of locus coeruleus by serotonin influences the anxiolytic effect in two different experimentally modelled states of alarm. The participation of locus coeruleus and acidergic mechanisms in anxiety of diverse aversive genesis is discussed.

摘要

向大鼠蓝斑内微量注射多巴胺和谷氨酸，在“威胁情境”回避试验中不影响警觉状态，但在“光照部位”回避试验中会削弱警觉状态。在此脑区局部注射γ-氨基丁酸（GABA）和去甲肾上腺素中间代谢产物效应模拟物，在“威胁情境”回避试验中会削弱警觉状态，但在“光照部位”回避试验中无效。相反，5-羟色胺对蓝斑的化学刺激在两种不同的实验模拟警觉状态下影响抗焦虑效应。文中讨论了蓝斑和酸性机制在不同厌恶源引发的焦虑中的作用。

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