Lawson T L, Gomez J A, Margulis A R
Invest Radiol. 1975 May-Jun;10(3):212-24. doi: 10.1097/00004424-197505000-00005.
The large intestines of eight boxer dogs with canine histiocytic ulcerative colitis (CHUC) and 10 normal dogs were studied by in vivo angiography and postmortem microangiography. The vascular abnormalities were correlated with the gross and histologic pathology found at necropsy. The angiographic abnormalities were variable, non-specific and were gross indicators of disease. Intestinal segments with mild, focal inflammatory lesions appeared normal, while diseased segments with more extensive inflammatory change exhibited variable vascular dilatation and hypervascularity. Microangiograms of bowel specimens with an early mucosal lesion were normal. With increased disease severity, there was microvascular dilatation with attenuation of mucosal arterioles. Areas with focal or confluent ulcerations demonstrated complete disruption of the mucosal microvascular bed and replacement with the chaotic tangle of ectatic vessels, characteristic of granulation tissue. Anatomic arteriovenous shunts were not observed.
对8只患有犬组织细胞性溃疡性结肠炎（CHUC）的拳师犬和10只正常犬的大肠进行了体内血管造影和死后微血管造影研究。血管异常与尸检时发现的大体和组织病理学相关。血管造影异常具有多样性、非特异性，是疾病的大体指标。有轻度局灶性炎症病变的肠段外观正常，而炎症变化更广泛的患病肠段则表现出不同程度的血管扩张和血管增多。早期黏膜病变的肠标本微血管造影正常。随着疾病严重程度增加，出现微血管扩张，黏膜小动脉变细。有局灶性或融合性溃疡的区域显示黏膜微血管床完全破坏，被扩张血管的混乱缠结所取代，这是肉芽组织的特征。未观察到解剖学上的动静脉分流。
