Taha Y, Carlson M, Thorn M, Loof L, Raab Y
Department of Internal Medicine, Clinical Chemistry and Surgery, University Hospital, Uppsala, Sweden.
Dig Dis Sci. 2001 Apr;46(4):888-97. doi: 10.1023/a:1010781224158.
The local release of the inflammatory mediators eosinophil cationic protein and myeloperoxidase and the permeability marker albumin was studied in collagenous colitis using a new technique for segmental perfusion of the rectum and descending colon. Perfusion of both segments was successful in 19/25 (76%) of patients with collagenous colitis and controls with noninflammatory conditions. The concentration of myeloperoxidase was increased in the perfusion fluids from both segments in only one patient with collagenous colitis and in none of the controls. On the other hand, concentrations of eosinophil cationic protein and albumin in the perfusate from the rectum were significantly increased in collagenous colitis compared with controls, and similar trends were seen in the perfusates from the descending colon. Furthermore, there was a significant correlation between the increased concentrations of eosinophil cationic protein and albumin, indicating a possible relation between eosinophil activation and disturbed mucosal permeability in collagenous colitis.
采用一种新的直肠和降结肠节段灌注技术，对胶原性结肠炎中炎症介质嗜酸性粒细胞阳离子蛋白和髓过氧化物酶的局部释放以及通透性标志物白蛋白进行了研究。在19/25（76%）的胶原性结肠炎患者和非炎症性疾病对照中，两个节段的灌注均成功。仅1例胶原性结肠炎患者两个节段的灌注液中髓过氧化物酶浓度升高，而对照组无一例升高。另一方面，与对照组相比，胶原性结肠炎患者直肠灌注液中嗜酸性粒细胞阳离子蛋白和白蛋白的浓度显著升高，降结肠灌注液中也出现类似趋势。此外，嗜酸性粒细胞阳离子蛋白和白蛋白浓度升高之间存在显著相关性，表明胶原性结肠炎中嗜酸性粒细胞活化与黏膜通透性紊乱之间可能存在关联。
