Pine D S, Goldstein R B, Wolk S, Weissman M M
Division of Child Psychiatry, New York State Psychiatric Institute and Columbia University, New York, New York 10032, USA.
Pediatrics. 2001 May;107(5):1049-56. doi: 10.1542/peds.107.5.1049.
Stress in childhood relates to both childhood depression and elevated adult body mass index (BMI), a measure of relative overweight. However, there are limited data on the association between major depression in childhood and BMI in adulthood. The current study examines this association.
Children 6 to 17 years old with major depression (n = 90) or no psychiatric disorder (n = 87) were identified at Columbia Presbyterian Medical Center and followed up 10 to 15 years later. Psychiatric status at intake and follow-up was assessed via standardized psychiatric interviews. BMI during adulthood was recorded so that the association between depression and BMI could be considered over time.
Participants with childhood major depression had a BMI of 26.1 +/- 5.2 as adults, compared with a BMI of 24.2 +/- 4.1 in healthy comparisons (t(175) = 2.7). This association could not be explained by a number of potentially confounding factors, including age, gender, cigarette or alcohol use, social class, and pregnancy or medication history. Although poverty during adulthood also predicted adult BMI, both the association between poverty and adult BMI (t(152) = 2.9), as well as between childhood depression and adult BMI (t(152) = 2.2) were significant in a multivariate model. Finally, duration of depression between childhood and adulthood also emerged as a predictor of adult BMI.
Depression during childhood is positively associated with BMI during adulthood. This association cannot be explained by various potential confounding variables and may develop over time as children pass into their adult years.body mass index, depression, children, adolescents.
童年期压力与儿童期抑郁及成人期体重指数（BMI，一种衡量相对超重的指标）升高均相关。然而，关于儿童期重度抑郁与成人期BMI之间关联的数据有限。本研究对这种关联进行了考察。
在哥伦比亚长老会医学中心识别出90名患有重度抑郁的6至17岁儿童及87名无精神疾病的儿童，并在10至15年后对其进行随访。通过标准化精神科访谈评估入组时及随访时的精神状态。记录成年期的BMI，以便能随时间推移考量抑郁与BMI之间的关联。
童年期患有重度抑郁的参与者成年后的BMI为26.1±5.2，而健康对照者的BMI为24.2±4.1（t(175)=2.7）。这种关联无法用一些潜在的混杂因素来解释，这些因素包括年龄、性别、吸烟或饮酒情况、社会阶层以及妊娠或用药史。尽管成年期贫困也可预测成人BMI，但在多变量模型中，贫困与成人BMI之间的关联（t(152)=2.9）以及童年期抑郁与成人BMI之间的关联（t(152)=2.2）均具有显著性。最后，童年期至成年期的抑郁持续时间也成为成人BMI的一个预测因素。
童年期抑郁与成年期BMI呈正相关。这种关联无法用各种潜在的混杂变量来解释，且可能随着儿童步入成年而随时间发展。体重指数、抑郁、儿童、青少年。
