Szekanecz Z, Koch A E
Third Department of Medicine, University of Debrecen Medical and Health Sciences Center, Debrecen, Hungary.
Curr Opin Rheumatol. 2001 May;13(3):202-8. doi: 10.1097/00002281-200105000-00009.
Chemokines mediate the ingress of leukocytes, including neutrophils and monocytes, into the inflamed synovium. Among the four known chemokine families, C-X-C and C-C chemokines seem to be of outstanding importance in this process. Angiogenesis, the formation of new vessels, is also important in the pathogenesis of rheumatoid arthritis. In this review, the authors discuss the role of the most important chemokines in the pathogenesis of rheumatoid synovitis. The most relevant angiogenic factors and angiogenesis inhibitors involved in rheumatoid arthritis are also discussed. Because certain chemokines may also play a role in neovascularization, chemokines and the process of angiogenesis are described in this context as well. Apart from discussing the pathogenic role of these factors, the authors also review the important relevance of chemokines and angiogenesis for therapeutic intervention.
趋化因子介导包括中性粒细胞和单核细胞在内的白细胞进入炎症滑膜。在已知的四个趋化因子家族中，C-X-C和C-C趋化因子在此过程中似乎尤为重要。血管生成，即新血管的形成，在类风湿性关节炎的发病机制中也很重要。在这篇综述中，作者讨论了最重要的趋化因子在类风湿性滑膜炎发病机制中的作用。还讨论了类风湿性关节炎中最相关的血管生成因子和血管生成抑制剂。由于某些趋化因子可能在新血管形成中也起作用，因此在此背景下也描述了趋化因子和血管生成过程。除了讨论这些因素的致病作用外，作者还综述了趋化因子和血管生成在治疗干预中的重要相关性。
