Szekanecz Zoltán, Szücs Gabriella, Szántó Sándor, Koch Alisa E
Division of Rheumatology, Third Department of Medicine, University of Debrecen Medical and Health Sciences Center, Debrecen, H-4004, Hungary.
Curr Drug Targets. 2006 Jan;7(1):91-102. doi: 10.2174/138945006775270231.
Chemotactic cytokines, termed chemokines, mediate the ingress of leukocytes into the inflamed synovium. In this review, authors discuss the role of the most relevant chemokines and chemokine receptors involved in chronic inflammatory rheumatic diseases. Rheumatoid arthritis was chosen as a prototype to discuss these issues, as the majority of studies on the role of chemokines in inflammatory diseases were carried out in arthritis. However, other rheumatic diseases including systemic lupus erythematosus, systemic sclerosis, Sjögren's syndrome, mixed connective tissue disease, polymyositis/dermatomyositis, antiphospholipid syndrome and systemic vasculitides are also discussed in this context. Apart from discussing the pathogenic role of chemokines and their receptors, authors also review the regulation of chemokine production by other inflammatory mediators, as well as the important relevance of chemokines for antirheumatic therapies.
趋化性细胞因子，即趋化因子，介导白细胞进入炎症滑膜。在本综述中，作者讨论了参与慢性炎症性风湿性疾病的最相关趋化因子和趋化因子受体的作用。类风湿性关节炎被选作讨论这些问题的原型，因为大多数关于趋化因子在炎症性疾病中作用的研究都是在关节炎中进行的。然而，本文也讨论了其他风湿性疾病，包括系统性红斑狼疮、系统性硬化症、干燥综合征、混合性结缔组织病、多发性肌炎/皮肌炎、抗磷脂综合征和系统性血管炎。除了讨论趋化因子及其受体的致病作用外，作者还综述了其他炎症介质对趋化因子产生的调节，以及趋化因子在抗风湿治疗中的重要意义。
