Djeridane Y, Khavinson V Kh, Anisimov V N, Touitou Y
Faculty of Medicine Pitié-Salpêtrière, Medical Biochemistry and Molecular Biology, Paris, France.
J Endocrinol Invest. 2003 Mar;26(3):211-5. doi: 10.1007/BF03345159.
The pineal gland contains many peptides known to be implicated in melatonin production. We examined the effects of a synthetic pineal tetrapeptide Ala-Glu-Asp-Gly on melatonin secretion by the pineal gland. The tetrapeptide effects on pineal gland melatonin secretion were studied in young (9 weeks) and old (27 months) male Wistar rats using a perifusion device. Pineal tetrapeptide at the concentrations used (10(-4) to 10(-6) M) had no significant effect upon melatonin secretion whatever the age of the animals, young or old. We also looked at the effect of the tetrapeptide on pineal melatonin stimulated by a beta-adrenergic agonist, isoproterenol. We found that isoproterenol-induced melatonin increase was not modified by the tetrapeptide. Our results suggest that the pineal tetrapeptide Ala-Glu-Asp-Gly, does not seem to play a role, at least in vitro, in the control of melatonin secretion by the rat pineal gland.
松果体含有许多已知与褪黑素产生有关的肽。我们研究了合成的松果体四肽Ala-Glu-Asp-Gly对松果体褪黑素分泌的影响。使用灌流装置，在年轻（9周）和年老（27个月）的雄性Wistar大鼠中研究了该四肽对松果体褪黑素分泌的影响。无论动物年龄大小，所用浓度（10^(-4)至10^(-6) M）的松果体四肽对褪黑素分泌均无显著影响。我们还研究了该四肽对由β-肾上腺素能激动剂异丙肾上腺素刺激的松果体褪黑素的影响。我们发现，四肽不会改变异丙肾上腺素诱导的褪黑素增加。我们的结果表明，松果体四肽Ala-Glu-Asp-Gly至少在体外似乎在大鼠松果体褪黑素分泌的控制中不起作用。
