Khuder S A, Mutgi A B
Department of Medicine, Medical College of Ohio, 3120 Glendale Ave, Toledo, Ohio, 43614-5809, USA.
Br J Cancer. 2001 May 4;84(9):1188-92. doi: 10.1054/bjoc.2000.1709.
Recent epidemiological studies suggest that non-steroidal anti-inflammatory drugs (NSAIDs) reduce the risk of several cancers including breast cancer. This meta-analysis examined the studies on NSAID use and breast cancer. The estimators of relative risk and associated variances, which have been adjusted for the greatest number of confounders, were abstracted and included in the meta-analysis. Combined estimators of relative risk (RR) were calculated using either fixed or random effect models. Meta-analyses were performed on 6 cohort studies (number of cases ranged from 14 to 2414) and 8 case-control studies (number of cases ranged from 252 to 5882). The combined estimate of relative risk was 0.82 (95% confidence interval [CI] = 0.75-0.89). The combined estimate for cohort studies was 0.78 (95% CI = 0.62-0.99) and was 0.87 (95% CI = 0.84-0.91) for case-control studies. The findings of this meta-analysis suggest that NSAID use may be associated with a small decrease in the risk of breast cancer. However, the available data are insufficient to estimate the dose-response effect for duration and frequency of use of any particular types of NSAID.
近期的流行病学研究表明，非甾体抗炎药（NSAIDs）可降低包括乳腺癌在内的多种癌症的发病风险。本荟萃分析对有关NSAIDs使用与乳腺癌的研究进行了审查。提取了针对最多混杂因素进行调整后的相对风险估计值及相关方差，并纳入荟萃分析。使用固定效应模型或随机效应模型计算相对风险（RR）的合并估计值。对6项队列研究（病例数从14例至2414例不等）和8项病例对照研究（病例数从252例至5882例不等）进行了荟萃分析。相对风险的合并估计值为0.82（95%置信区间[CI]=0.75 - 0.89）。队列研究的合并估计值为0.78（95%CI = 0.62 - 0.99），病例对照研究的合并估计值为0.87（95%CI = 0.84 - 0.91）。该荟萃分析的结果表明，使用NSAIDs可能与乳腺癌风险的小幅降低有关。然而，现有数据不足以估计任何特定类型NSAIDs使用的持续时间和频率的剂量反应效应。
