Harris R E, Kasbari S, Farrar W B
The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.
Oncol Rep. 1999 Jan-Feb;6(1):71-3.
We conducted a prospective cohort study of Nonsteroidal anti-inflammatory drugs (NSAIDs) and breast cancer among 32,505 women in central Ohio, USA. After 5 years of follow-up, a total of 393 cases have been detected. The annual incidence of breast cancer per 100,00 women varied inversely with increasing intake of NSAIDs, declining from 323 among non-users to 183 among heavy users (p<0.01). Breast cancer rates decreased by about 50% with regular ibuprofen intake (p<0.01), and by about 40% with regular aspirin intake (p<0.05). The results suggest that specific NSAIDs may be effective chemopreventive agents against breast cancer.
我们在美国俄亥俄州中部的32505名女性中开展了一项关于非甾体抗炎药（NSAIDs）与乳腺癌的前瞻性队列研究。经过5年的随访，共检测到393例病例。每10万名女性中乳腺癌的年发病率与NSAIDs摄入量的增加呈负相关，从非使用者中的323例降至大量使用者中的183例（p<0.01）。定期服用布洛芬可使乳腺癌发病率降低约50%（p<0.01），定期服用阿司匹林可使发病率降低约40%（p<0.05）。结果表明，特定的NSAIDs可能是预防乳腺癌的有效化学预防剂。
