Lacave G, Cox E, Hermans J, Devriese L, Goddeeris B M
Marine Mammal Veterinary Services, Betferkerklaan 158, 8200 Brugge, Belgium.
Vet Microbiol. 2001 Jun 6;80(3):247-53. doi: 10.1016/s0378-1135(01)00311-x.
Erysipelothrix rhusiopathiae is well known to cause disease in dolphins. This disease occurs either in an peracute way, leading to mortality even before clinical signs are observed or in a sub-acute way, characterized by rhomboidal skin lesions, that can be treated with penicillin or its derivatives. Commercial swine vaccines, containing inactivated serotype 2 strains, are currently used for vaccination but it is not known whether these vaccines induce protection against E. rhusiopathiae isolates from dolphins. In the present study, it was demonstrated in a mouse model that vaccination with a commercial swine vaccine (Eurovac Ery, Eurovet, Belgium) containing inactivated serotype 2 E. rhusiopathiae strains induced protection against challenge with three E. rhusiopathiae isolates from dolphins. The duration of the protection varied, depending on the challenging isolate, between 8 and >23 weeks. There was however no positive correlation between the amount of antibodies at the moment of challenge and the observed protection. In conclusion, vaccination trials in mice indicate that commercial serotype 2 swine Erysipelothrix vaccines induce protection against erysipelas caused by dolphin pathogenic isolates.
猪红斑丹毒丝菌已知可在海豚中引发疾病。这种疾病要么以超急性方式发生，甚至在观察到临床症状之前就导致死亡，要么以亚急性方式发生，其特征为菱形皮肤损伤，可用青霉素或其衍生物进行治疗。目前使用含有2型灭活菌株的商业猪疫苗进行接种，但尚不清楚这些疫苗是否能诱导对来自海豚的猪红斑丹毒丝菌分离株产生保护作用。在本研究中，在小鼠模型中证明，用含有2型灭活猪红斑丹毒丝菌菌株的商业猪疫苗（Eurovac Ery，Eurovet，比利时）进行接种可诱导对三种来自海豚的猪红斑丹毒丝菌分离株的攻击产生保护作用。保护持续时间因攻击的分离株而异，在8至>23周之间。然而，攻击时的抗体量与观察到的保护作用之间没有正相关。总之，小鼠接种试验表明，2型商业猪红斑丹毒丝菌疫苗可诱导对海豚致病性分离株引起的丹毒产生保护作用。
