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用猪丹毒活疫苗免疫的小鼠和猪对不同血清型的猪红斑丹毒丝菌菌株攻击暴露的交叉保护作用。

Cross protection in mice and swine immunized with live erysipelas vaccine to challenge exposure with strains of Erysipelothrix rhusiopathiae of various serotypes.

作者信息

Takahashi T, Takagi M, Sawada T, Seto K

出版信息

Am J Vet Res. 1984 Oct;45(10):2115-8.

PMID:6497110
Abstract

Mice and swine immunized subcutaneously with live vaccine prepared from acriflavine-fast attenuated Erysipelothrix rhusiopathiae, strain Koganei (serotype 2), were challenge exposed to virulent strains of E rhusiopathiae of various serotypes. Vaccinated mice did not die after challenge exposure to serotypes 1a, 1b, 2, 3, 5, 6, 7, 8, 9, 11, 12, 15, 16, 18, 19, 21, or N, but 20% to 30% mortality occurred in vaccinated mice challenge exposed to serotypes 10, 14, 20, or 22. Nonvaccinated control mice died after challenge exposure to all serotypes tested. Vaccinated swine challenge exposed to strain 14B (serotype 9) or strain 2179 (serotype 10) developed localized urticarial lesions at the site of intradermal exposure. Vaccinated swine challenge exposed to serotypes 1a, 1b, 2, 5, 8, 11, 12, 18, 19, or 21 did not have clinical signs of acute erysipelas. Nonvaccinated control swine developed acute generalized erysipelas or localized lesions at the site of intradermal exposure.

摘要

用由抗吖啶黄减毒的猪丹毒杆菌小贺菌株(血清型2)制备的活疫苗皮下免疫的小鼠和猪,接受了各种血清型的猪丹毒强毒株的攻击。接种疫苗的小鼠在接受血清型1a、1b、2、3、5、6、7、8、9、11、12、15、16、18、19、21或N的攻击后未死亡,但在接受血清型10、14、20或22攻击的接种疫苗的小鼠中出现了20%至30%的死亡率。未接种疫苗的对照小鼠在接受所有测试血清型的攻击后死亡。接种疫苗的猪在接受14B菌株(血清型9)或2179菌株(血清型10)攻击后,在皮内暴露部位出现局部荨麻疹病变。接种疫苗的猪在接受血清型1a、1b、2、5、8、11、12、18、19或21攻击后没有急性丹毒的临床症状。未接种疫苗的对照猪出现了急性全身性丹毒或皮内暴露部位的局部病变。

相似文献

1
Cross protection in mice and swine immunized with live erysipelas vaccine to challenge exposure with strains of Erysipelothrix rhusiopathiae of various serotypes.用猪丹毒活疫苗免疫的小鼠和猪对不同血清型的猪红斑丹毒丝菌菌株攻击暴露的交叉保护作用。
Am J Vet Res. 1984 Oct;45(10):2115-8.
2
Cross protection of mice and swine inoculated with culture filtrate of attenuated Erysipelothrix rhusiopathiae and challenge exposed to strains of various serovars.用减毒猪丹毒杆菌培养滤液接种的小鼠和猪的交叉保护作用以及对暴露于各种血清型菌株的攻击试验。
Am J Vet Res. 1987 Feb;48(2):239-42.
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Cross protection of mice and swine given live-organism vaccine against challenge exposure with strains of Erysipelothrix rhusiopathiae representing ten serovars.用活生物体疫苗对小鼠和猪进行交叉保护,使其免受代表10个血清型的猪丹毒杆菌菌株的攻击暴露。
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Susceptibility of vaccinated swine and mice to generalized infection with specific serotypes of Erysipelothrix rhusiopathiae.接种疫苗的猪和小鼠对特定血清型猪丹毒杆菌全身感染的易感性。
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