Wood R L, Booth G D, Cutlip R C
Am J Vet Res. 1981 Apr;42(4):608-14.
Swine were vaccinated with adsorbate bacterin made from Erysipelothrix rhusiopathiae of serotype 2 and were subsequently allotted to 4 exposure groups, each of which was exposed to 1 of the strains of E rhusiopathiae of serotypes 1, 2, 9, or 10. Mice were vaccinated with the same bacterin and were subsequently allotted to 60 exposure groups which were exposed to 60 strains of E rhusiopathiae, comprising 10 strains each of serotypes 1, 2, 4, 9, 10, and 11. Response to challenge of immunity in swine was determined by the presence of clinical signs of acute generalized erysipelas; response in mice was determined by the quantal (live-dead) method. Vaccinated swine were as susceptible to the strain of serotype 10 as were nonvaccinated control swine, whereas vaccinated swine were immune and control swine were susceptible to the strains of serotypes 1 and 2. The strain of serotype 9 was not sufficiently virulent to induce acute generalized erysipelas, even in control swine. Arthritis was not prevented by vaccination, but its frequency and severity were less in vaccinated swine exposed to strains of serotype 1 or 2 than in those exposed to strains of serotype 9 or 10. Vaccinated mice were significantly (P less than 0.05) more susceptible to the strains of serotype 10 than to those of any other serotype tested.
用由2型猪丹毒杆菌制成的吸附菌苗对猪进行接种，随后将其分为4个暴露组，每组暴露于1型、2型、9型或10型猪丹毒杆菌菌株中的一种。用相同的菌苗对小鼠进行接种，随后将其分为60个暴露组，使其暴露于60株猪丹毒杆菌，其中包括1型、2型、4型、9型、10型和11型各10株。通过急性全身性丹毒的临床症状来确定猪对免疫攻击的反应；通过定量（活-死）法来确定小鼠的反应。接种疫苗的猪对10型菌株的易感性与未接种疫苗的对照猪相同，而接种疫苗的猪对1型和2型菌株具有免疫力，对照猪则易感。9型菌株的毒力不足以诱发急性全身性丹毒，即使在对照猪中也是如此。接种疫苗不能预防关节炎，但接种疫苗的猪在暴露于1型或2型菌株时，关节炎的发生率和严重程度低于暴露于9型或10型菌株的猪。接种疫苗的小鼠对10型菌株的易感性显著（P小于0.05）高于对所测试的任何其他血清型菌株的易感性。
