Alves S H, Milan E P, Branchini M L, Nishimura K, Fukushima K, Oliveira L O, Costa J M, Colombo A L
Hospital Universitário de Santa Maria, Universidade Federal de Santa Maria, (RS), Santa Maria, Brazil.
Diagn Microbiol Infect Dis. 2001 Mar;39(3):165-8. doi: 10.1016/s0732-8893(01)00220-6.
Candida dubliniensis is a newly recognized species closely phylogenetically related to Candida albicans and is commonly associated with oral candidiasis in human immunodeficiency virus-positive patients. In this paper we report the isolation of three strains of C. dubliniensis, from AIDS patients, in the state of Rio Grande do Sul (Brazil). The phenotypic identification was based on germ tube emission, abundant production of chlamydospores, assimilation of sucrose but not of xylose and the inability to grow at 42 degrees C. Randomly amplified polymorphic DNA (RAPD) analysis and genomic DNA sequencing confirmed the distinct genetic nature C. dubliniensis. Topics related to the epidemiology, isolation, phenotypical and genotypical identification of C. dubliniensis are also discussed.
都柏林念珠菌是一种新发现的与白色念珠菌在系统发育上密切相关的菌种，通常与人类免疫缺陷病毒阳性患者的口腔念珠菌病有关。在本文中，我们报告了从巴西南里奥格兰德州的艾滋病患者中分离出三株都柏林念珠菌。表型鉴定基于芽管形成、大量厚垣孢子产生、蔗糖同化但木糖不同化以及无法在42℃生长。随机扩增多态性DNA（RAPD）分析和基因组DNA测序证实了都柏林念珠菌独特的遗传特性。还讨论了与都柏林念珠菌的流行病学、分离、表型和基因型鉴定相关的主题。
