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5-羟色胺刺激丽蝇离体唾液腺时的膜通透性变化。

Membrane permeability changes during stimulation of isolated salivary glands of Calliphora by 5-hydroxytryptamine.

作者信息

Berridge M J, Lindley B D, Prince W T

出版信息

J Physiol. 1975 Jan;244(3):549-67. doi: 10.1113/jphysiol.1975.sp010812.

DOI:10.1113/jphysiol.1975.sp010812
PMID:1133770
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1330822/
Abstract
  1. The membrane resistance of isolated salivary glands was found to decrease in response to 5-HT. The change in resistance was calcium-dependent. 2. The resistance change of the apical membrane was found to be much greater than the change in resistance of the basal membrane. 3. Potential responses under current-clamped conditions showed that one part of the biphasic response to 5-HT (attributed to an increase in chloride permeability) could be reversed and the other part (attributed to an increase in a potassium pump) could not. 4. These observations have been incorporated into a model which, on evaluation, predicts all of the observed potential changes during the action of 5-HT. It suggests that the potential responses reflect changes in the internal chloride concentration produced by the calcium-dependent increases in chloride permeability.
摘要
  1. 研究发现，分离出的唾液腺的膜电阻会因5-羟色胺（5-HT）而降低。电阻变化依赖于钙。2. 发现顶端膜的电阻变化远大于基底膜的电阻变化。3. 在钳制电流条件下的电位反应表明，对5-HT双相反应的一部分（归因于氯离子通透性增加）可以逆转，而另一部分（归因于钾泵增加）则不能。4. 这些观察结果已被纳入一个模型，经评估，该模型预测了5-HT作用期间所有观察到的电位变化。这表明电位反应反映了由氯离子通透性的钙依赖性增加所导致的细胞内氯离子浓度的变化。

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本文引用的文献

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The site of the stimulatory action of vasopressin on sodium transport in toad bladder.血管加压素对蟾蜍膀胱钠转运的刺激作用部位。
J Gen Physiol. 1968 May;51(5):589-605. doi: 10.1085/jgp.51.5.589.
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Effects of noradrenaline on potassium reflux, membrane potential and electrolyte levels in tissue slices prepared from guinea-pig liver.去甲肾上腺素对豚鼠肝脏制备的组织切片中钾反流、膜电位和电解质水平的影响。
J Physiol. 1972 Sep;225(3):721-50. doi: 10.1113/jphysiol.1972.sp009966.
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Pancreatic acinar cells: membrane potential and resistance change evoked by acetylcholine.胰腺腺泡细胞：乙酰胆碱引起的膜电位和电阻变化
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Conductance changes associated with the secretory potential in the cockroach salivary gland.蟑螂唾液腺中与分泌电位相关的电导变化。
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Transepithelial potential changes during stimulation of isolated salivary glands with 5-hydroxytryptamine and cyclic AMP.用5-羟色胺和环磷酸腺苷刺激离体唾液腺时的跨上皮电位变化。
J Exp Biol. 1972 Feb;56(1):139-53. doi: 10.1242/jeb.56.1.139.
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J Exp Biol. 1972 Apr;56(2):323-33. doi: 10.1242/jeb.56.2.323.
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Role of calcium and adenosine-3':5'-cyclic monophosphate in controlling fly salivary gland secretion.钙和3':5'-环磷酸腺苷在控制果蝇唾液腺分泌中的作用。
Proc Natl Acad Sci U S A. 1972 Mar;69(3):553-7. doi: 10.1073/pnas.69.3.553.
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The role of 5-hydroxytryptamine and cyclic AMP in the control of fluid secretion by isolated salivary glands.5-羟色胺和环磷酸腺苷在离体唾液腺液体分泌控制中的作用。
J Exp Biol. 1970 Aug;53(1):171-86. doi: 10.1242/jeb.53.1.171.
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Insect salivary glands: stimulation of fluid secretion by 5-hydroxytryptamine and adenosine-3',5'-monophosphate.昆虫唾液腺：5-羟色胺和3',5'-环磷酸腺苷对液体分泌的刺激作用
Science. 1968 Oct 25;162(3852):462-3. doi: 10.1126/science.162.3852.462.