Wohlrab J, Vollmann A, Wartewig S, Marsch W C, Neubert R
Department of Dermatology, Martin-Luther-University Halle-Wittenberg, Ernst-Kromayer-Strasse 5-6, D-06097 Halle, Germany.
Biopolymers. 2001;62(3):141-6. doi: 10.1002/bip.1006.
Etiopathogenetic regulatory disorders of epidermal metabolism and the subsequent changes in the molecular pattern of the stratum corneum play an important role in the clinical differentiation of particular dermatoses (e.g., psoriasis, atopic dermatitis). In this study we present in vitro Fourier transform Raman spectra of the stratum corneum from healthy skin, as well as from clinically undiseased skin of the right heel of atopic and psoriatic volunteers. Differences in the averaged spectra were detected, particularly in the spectral ranges of 1112-1142 (lipid band), 1185-1220, and 1394-1429 cm(-1). By using the first derivative of the averaged spectra and/or a statistical evaluation of the spectroscopic data it was possible to distinguish the skin types examined.
表皮新陈代谢的病因发病机制调节紊乱以及随后角质层分子模式的变化在特定皮肤病（如银屑病、特应性皮炎）的临床鉴别中起重要作用。在本研究中，我们展示了来自健康皮肤以及特应性和银屑病志愿者右足跟临床未患病皮肤的角质层的体外傅里叶变换拉曼光谱。检测到平均光谱存在差异，特别是在1112 - 1142（脂质带）、1185 - 1220和1394 - 1429 cm(-1)的光谱范围内。通过使用平均光谱的一阶导数和/或光谱数据的统计评估，可以区分所检查的皮肤类型。
