Loeb G E, Peck R A, Moore W H, Hood K
A.E. Mann Institute for Biomedical Engineering, University of Southern California, 1042 West 36th Place, Room B-12, Los Angeles, CA 90089-1112, USA.
Med Eng Phys. 2001 Jan;23(1):9-18. doi: 10.1016/s1350-4533(01)00011-x.
We have developed the first in a planned series of neural prosthetic interfaces that allow multichannel systems to be assembled from single-channel micromodules called BIONs (BIOnic Neurons). Multiple BION implants can be injected directly into the sites requiring stimulating or sensing channels, where they receive power and digital commands by inductive coupling to an externally generated radio-frequency magnetic field. This article describes some of the novel technology required to achieve the required microminiaturization, hermeticity, power efficiency and clinical performance. The BION1 implants are now being used to electrically exercise paralyzed and weak muscles to prevent or reverse disuse atrophy. This modular, wireless approach to interfacing with the peripheral nervous system should facilitate the development of progressively more complex systems required to address a growing range of clinical applications, leading ultimately to synthesizing complete voluntary functions such as reach and grasp.
我们已经开发出了计划中的一系列神经假体接口中的首个接口，该接口可让多通道系统由称为BIONs（仿生神经元）的单通道微模块组装而成。多个BION植入物可直接注入需要刺激或传感通道的部位，在那里它们通过与外部产生的射频磁场进行感应耦合来接收电力和数字指令。本文描述了实现所需的微型化、密封性、功率效率和临床性能所需的一些新技术。目前，BION1植入物正被用于对瘫痪和无力的肌肉进行电刺激锻炼，以预防或扭转废用性萎缩。这种与外周神经系统对接的模块化、无线方法应有助于开发越来越复杂的系统，以满足不断增加的临床应用需求，最终实现诸如伸手和抓握等完整自主功能的合成。
