Kadmon P M, Noto R B, Boney C M, Goodwin G, Gruppuso P A
Department of Pediatrics, Rhode Island Hospital and Brown University, Providence, Rhode Island 02903, USA.
J Clin Endocrinol Metab. 2001 May;86(5):1865-7. doi: 10.1210/jcem.86.5.7473.
A 7.5-yr-old boy with Graves' disease, difficult to control with antithyroid medication and radioactive iodine (RAI) therapy, developed thyroid storm encephalopathy on day 13 after withdrawal of methimazole therapy, 4 days after iodine-131 treatment. We attributed his thyroid storm to withdrawal of antithyroid medication as opposed to RAI therapy. We interpret this case as indicating that there may be a need to reevaluate the duration of antithyroid medication withdrawal before RAI therapy for hyperthyroid children at increased risk for thyroid storm.
