LaBar K S, Gitelman D R, Parrish T B, Kim Y H, Nobre A C, Mesulam M M
Department of Psychology: Experimental, Duke University, Durham, North Carolina 27708-0999, USA.
Behav Neurosci. 2001 Apr;115(2):493-500. doi: 10.1037/0735-7044.115.2.493.
Functional magnetic resonance imaging (fMRI) was used to determine whether visual responses to food in the human amygdala and related corticolimbic structures would be selectively altered by changes in states of hunger. Participants viewed images of motivationally relevant (food) and motivationally irrelevant (tool) objects while undergoing fMRI in alternately hungry and satiated conditions. Food-related visual stimuli elicited greater responses in the amygdala, parahippocampal gyrus. and anterior fusiform gyrus when participants were in a hungry state relative to a satiated state. The state-dependent activation of these brain structures did not generalize to the motivationally irrelevant objects. These results support the hypothesis that the amygdala and associated inferotemporal regions are involved in the integration of subjective interoceptive states with relevant sensory cues processed along the ventral visual stream.
功能磁共振成像（fMRI）被用于确定饥饿状态的变化是否会选择性地改变人类杏仁核及相关皮质边缘结构对食物的视觉反应。参与者在交替处于饥饿和饱腹状态下接受fMRI扫描时，观看了动机相关（食物）和动机无关（工具）物体的图像。与饱腹状态相比，当参与者处于饥饿状态时，与食物相关的视觉刺激在杏仁核、海马旁回和梭状回前部引发了更大的反应。这些脑结构的状态依赖性激活并未扩展到动机无关的物体上。这些结果支持了以下假设：杏仁核及相关颞下区域参与了主观内感受状态与沿腹侧视觉通路处理的相关感觉线索的整合。
