Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Curr Opin Neurobiol. 2018 Apr;49:16-23. doi: 10.1016/j.conb.2017.10.020. Epub 2017 Nov 8.
Physiological need states and associated motivational drives can bias visual processing of cues that help meet these needs. Human neuroimaging studies consistently show a hunger-dependent, selective enhancement of responses to images of food in association cortex and amygdala. More recently, cellular-resolution imaging combined with circuit mapping experiments in behaving mice have revealed underlying neuronal population dynamics and enabled tracing of pathways by which hunger circuits influence the assignment of value to visual objects in visual association cortex, insular cortex, and amygdala. These experiments begin to provide a mechanistic understanding of motivation-specific neural processing of need-relevant cues in healthy humans and in disease states such as obesity and other eating disorders.
生理需求状态和相关的动机驱动会影响视觉处理有助于满足这些需求的线索。人类神经影像学研究一致表明，在与食物相关的联合皮层和杏仁核中，对食物图像的反应存在饥饿依赖性的选择性增强。最近，在行为小鼠中进行的细胞分辨率成像结合电路映射实验揭示了潜在的神经元群体动力学，并能够追踪饥饿回路影响视觉联合皮层、岛叶和杏仁核中视觉对象赋值的途径。这些实验开始提供对健康人类和肥胖症等疾病状态下与需求相关的线索的动机特异性神经处理的机制理解。
