新型喹啉-4-羧酸和喹啉-4-甲酰胺衍生物的一些生物学特性

Some biological properties of new quinoline-4-carboxylic acid and quinoline-4-carboxamide derivatives.

作者信息

Strigácová J, Hudecová D, Varecka L, Lásiková A, Végh D

机构信息

Department of Biochemistry and Microbiology, Faculty of Chemical Technology, Slovak University of Technology, 812 37 Bratislava, Slovakia.

出版信息

Folia Microbiol (Praha). 2000;45(4):305-9. doi: 10.1007/BF02817551.

DOI:10.1007/BF02817551

PMID:11347250

Abstract

The antimicrobial and morphogenetic effects of fourteen newly synthesized 2-substituted derivatives of quinoline-4-carboxylic acid and quinoline-4-carboxamide were studied using G+ and G- bacteria, yeasts and filamentous fungi. The highest antimicrobial effects were found with substituted quinoline-4-carboxylic acid derivatives. Quinoline-4-carboxamides only weakly influenced the growth of the tested microorganisms. Some derivatives of quinoline-4-carboxylic acid elicited profound changes in the morphology of hyphal tips of Botrytis cinerea, mainly their branching and the release of the cytoplasmic content. Quinoline derivatives, which elicited morphological changes, increased also the permeability of the plasmalemma of plant cells.

摘要

使用革兰氏阳性菌、革兰氏阴性菌、酵母和丝状真菌研究了14种新合成的喹啉-4-羧酸和喹啉-4-甲酰胺的2-取代衍生物的抗菌和形态发生作用。发现取代的喹啉-4-羧酸衍生物具有最高的抗菌效果。喹啉-4-甲酰胺仅对受试微生物的生长有微弱影响。喹啉-4-羧酸的一些衍生物引起了灰葡萄孢菌菌丝尖端形态的深刻变化，主要是它们的分支和细胞质内容物的释放。引起形态变化的喹啉衍生物也增加了植物细胞质膜的通透性。