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新型叠氮甲基金雀花碱及其生物活性。

New azidometalkojates and their biological activity.

作者信息

Hudecová D, Jantová S, Melník M, Uher M

机构信息

Department of Biochemistry and Microbiology, Faculty of Chemical Technology, Slovak Technical University, Bratislava, Slovakia.

出版信息

Folia Microbiol (Praha). 1996;41(6):473-6. doi: 10.1007/BF02814660.

Abstract

Azidometalkojates of the general formula MX2 (M = Cu, Mn, Mg, Zn or Ni and X = 5-hydroxy-2-azidomethyl-4H-pyran-4-one) were prepared and tested for antibacterial, antifungal and cytotoxic effects. The mangan and zinc derivatives are not active against any the tested microorganisms. A weak antibacterial activity was found with the copper derivative. The strongest antifungal effects were shown by the nickel derivative while the highest cytotoxic effect on HeLa cells was manifested by the zinc derivative.

摘要

制备了通式为MX2(M = Cu、Mn、Mg、Zn或Ni,X = 5-羟基-2-叠氮甲基-4H-吡喃-4-酮)的叠氮金属 kojates,并测试了它们的抗菌、抗真菌和细胞毒性作用。锰和锌衍生物对任何测试微生物均无活性。铜衍生物表现出较弱的抗菌活性。镍衍生物显示出最强的抗真菌作用,而锌衍生物对HeLa细胞表现出最高的细胞毒性作用。

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