亚胺培南与氧氟沙星对克雷伯菌属菌株酶活性的体外作用。
The in vitro effect of imipenem and ofloxacin on enzymic activity of Klebsiella strains.
作者信息
Hostacká A
机构信息
Institute of Preventive and Clinical Medicine, 833 01 Bratislava, Slovakia.
出版信息
Folia Microbiol (Praha). 2000;45(5):387-90. doi: 10.1007/BF02817610.
Fifty seven Klebsiella strains, viz. K. pneumoniae (28), K. planticola (19), K. oxytoca (6), K. ornithinolytica (3) and K. terrigena (1) possessed lipolytic and urealytic activity. The effect of imipenem and ofloxacin at subinhibitory concentrations (sub-MICs) on these enzymic activities of 4 strains was studied. At all the concentrations tested (mainly at 1/4 of the MICs) imipenem enhanced lipase activity manifested by cleavage of the substrate Tween 20. The effect of ofloxacin was strain- and concentration-dependent but in most cases lipolytic activity was also increased. The antibiotics practically did not affect the urease activity of the strains.
57株克雷伯菌，即肺炎克雷伯菌（28株）、植生克雷伯菌（19株）、产酸克雷伯菌（6株）、解鸟氨酸克雷伯菌（3株）和土生克雷伯菌（1株）具有脂解和尿素分解活性。研究了亚抑菌浓度（亚MIC）的亚胺培南和氧氟沙星对4株菌这些酶活性的影响。在所有测试浓度下（主要是MIC的1/4），亚胺培南通过底物吐温20的裂解增强了脂肪酶活性。氧氟沙星的作用具有菌株和浓度依赖性，但在大多数情况下脂解活性也增加。这些抗生素实际上不影响菌株的脲酶活性。
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