两性霉素C的绝对立体化学
Absolute stereochemistry of amphidinolide C.
作者信息
Kubota T, Tsuda M, Kobayashi J
机构信息
Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan.
出版信息
Org Lett. 2001 May 3;3(9):1363-6. doi: 10.1021/ol015741z.
PMID:11348235
Abstract
[structure in text] The absolute configurations at 12 chiral centers in amphidinolide C (1), a potent cytotoxic 25-membered macrolide isolated from a marine dinoflagellate Amphidinium sp., were determined to be 3S, 4R, 6R, 7R, 8R, 12R, 13S, 16S, 20R, 23R, 24R, and 29S by combination of NMR analyses, degradation experiments, and synthesis of the C-1-C-7 segment.
摘要
[文本中的结构] 从海洋双鞭毛藻Amphidinium sp.中分离出的具有强细胞毒性的25元大环内酯类化合物两性霉素C（1）中12个手性中心的绝对构型，通过核磁共振分析、降解实验以及C-1-C-7片段的合成相结合的方法确定为3S、4R、6R、7R、8R、12R、13S、16S、20R、23R、24R和29S。
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